Gomazkov O A, Oehme P
Institute of Biochemical Chemistry, Moscow, Russia.
Ross Fiziol Zh Im I M Sechenova. 1998 Oct;84(10):1139-45.
The data obtained suggest a potential mechanism that may account for the selective control of adrenaline and noradrenaline release from adrenal chromaffin cells. Some neuropeptides seem to affect in a different way the release from A- and NA-adrenal cells by means of regulating a set of cytochemical events: specific reception of cholinergic transmitters, expression of the second messenger system including cGMP and changes in Ca channels activity, changes in the catecholamine biosynthesis in adrenal chromaffin cells. Modulating function of substance P, endothelins, PACAP, and ANF, is discussed.
所获得的数据提示了一种潜在机制，该机制可能解释肾上腺嗜铬细胞中肾上腺素和去甲肾上腺素释放的选择性控制。一些神经肽似乎通过调节一系列细胞化学事件，以不同方式影响A-肾上腺细胞和去甲肾上腺素能肾上腺细胞的释放：胆碱能递质的特异性受体、包括环磷酸鸟苷在内的第二信使系统的表达以及钙通道活性的变化、肾上腺嗜铬细胞中儿茶酚胺生物合成的变化。文中讨论了P物质、内皮素、垂体腺苷酸环化酶激活肽和心房钠尿肽的调节功能。
