Tocchi A, Costa G, Lepre L, Liotta G, Mazzoni G, Miccini M
I Istituto di Clinica Chirurgica, Università degli Studi La Sapienza, Roma.
G Chir. 1999 Jan-Feb;20(1-2):9-13.
The effect of octreotide on splanchnic haemodynamics was investigated in 25 domestic pigs by mean of US-colordoppler. In a blind-operator design the superior mesenteric artery (SMA) blood flow was evaluated before and after i.m. injection of 5, 10, 20, 25 micrograms/kg or of an equivalent volume of saline solution. Seven serial measurements were taken every 10 min in each pig excluding the higher and the lower values. The administration of 5 and 10 micrograms/kg determined a rapid and stable (3 hours) decrease of the SMA blood flow (6 and 8.5% respectively) (p < 0.05). The blood flow decreased by 27-29% (p < 0.001) in response to the administration of 20 and 25 micrograms/kg respectively. The reduction started 30 min after injection and the blood flow remained lower than basal for up to 5 hours. Because of the mean standard error of US blood flow assessment is 10% due to the interobserver and intraobserver variations, we considered statistically significant only the reduction occurred after the administration of 20 or 25 micrograms/kg. Authors findings suggest that high dose of octreotide is effective in reducing the splanchnic haemodynamics in the pig. Such animal can be used in experimental setting planed to assess the effect of splanchnic blood flow reduction.
采用美国彩色多普勒技术，在25头家猪身上研究了奥曲肽对内脏血流动力学的影响。在一项由不知情操作人员进行的设计中，通过肌肉注射5、10、20、25微克/千克奥曲肽或等量生理盐水溶液，评估肠系膜上动脉（SMA）血流在注射前后的变化。每头猪每隔10分钟进行7次连续测量，排除最高值和最低值。注射5微克/千克和10微克/千克奥曲肽后，SMA血流迅速且稳定地（持续3小时）下降（分别下降6%和8.5%）（p<0.05）。注射20微克/千克和25微克/千克奥曲肽后，血流分别下降27%-29%（p<0.001）。血流减少在注射后30分钟开始，并且在长达5小时内血流一直低于基础水平。由于超声血流评估的平均标准误差因观察者间和观察者内差异为10%，我们仅认为注射20微克/千克或25微克/千克奥曲肽后出现的血流减少具有统计学意义。作者的研究结果表明，高剂量奥曲肽可有效降低猪的内脏血流动力学。这种动物可用于计划评估内脏血流减少效果的实验环境中。
