Hinton D R, Kovacs K, Chandrasoma P T
Department of Pathology, USC/University Hospital, Los Angeles County/USC Medical Center, University of Southern California School of Medicine 90033, USA.
Acta Cytol. 1999 Mar-Apr;43(2):121-5. doi: 10.1159/000330964.
To describe the cytologic features of secretory meningioma on crush preparations.
In five cases, the diagnosis of secretory meningioma was made and crush preparations were available. In each case, crush preparations were made at the time of intraoperative consultation from an open biopsy specimen or stereotactic biopsy.
Hematoxylin and eosin-stained crushes showed the presence of clusters of cohesive cells containing variable numbers of inclusions among less cohesive typical meningothelial cells. In two cases, the inclusions were especially prominent. Inclusions varied in size from 3 to 40 microns, had a well-defined rim and contained finely granular or hyaline material and a central core.
Secretory meningiomas demonstrate distinct cytologic features on crush preparations. Recognition of these inclusions is important since their prominence in some stereotactic smear preparations may lead to diagnostic problems.
