Holstein P E, Sørensen S
Department of Thoracic and Vascular Surgery I, Bispebjerg Hospital, University of Copenhagen, Denmark.
Diabetes Care. 1999 Mar;22 Suppl 2:B97-103.
To assess the results of the strategy used in avoiding major amputations in patients admitted to a vascular surgical department with a new multidisciplinary diabetic foot unit.
The study was retrospective. A total of 162 patients (172 limbs) were classified into three groups. Group A1 had limb-threatening ischemia and were undergoing revascularization (85 patients, 91 legs). Group A2 had limb-threatening ischemia, but revascularization was not feasible for them (23 patients). Group B had foot ulcers due to peripheral neuropathy and did not require arterial reconstruction (54 patients, 58 legs).
In group A1 there were 115 revascularizations; 42 conduits had outflow to crural arteries and 14 to pedal arteries. Resection of gangrene was required in 43% of the limbs. The chances of preserved limb at 1 and at 24 months were 95 and 85%, respectively, and the chances of patient survival were 89 and 64%. In group A2, the chances of preserved limb at 1 and at 24 months were only 35 and 17%, respectively, and the chances of patient survival were only 64 and 16%. In group B, 51 of 58 limbs suffered invasive infection; debridement of the ulcers required resection of toes or part of the foot in 64% of cases. The chances of preserved limb at 1 and at 24 months was 98 and 86%; the chances of patient survival were 98 and 68%. Ankle and toe systolic pressures were less suitable than repeated clinical examinations in deciding the need for revascularization.
Major amputation can be avoided in about 80% of patients with limb-threatening ischemia and in about 95% with foot ulceration complicated with infection. Multifactorial treatment of the complex foot lesions by a multidisciplinary foot care team is considered mandatory to obtain satisfactory limb salvage.
评估在设有新的多学科糖尿病足治疗单元的血管外科收治的患者中,采用避免大截肢策略的效果。
本研究为回顾性研究。共162例患者(172条肢体)被分为三组。A1组有肢体威胁性缺血且正在接受血运重建(85例患者,91条腿)。A2组有肢体威胁性缺血,但对其进行血运重建不可行(23例患者)。B组因周围神经病变有足部溃疡且无需动脉重建(54例患者,58条腿)。
A1组进行了115次血运重建;42条血管通路通向小腿动脉,14条通向足部动脉。43%的肢体需要切除坏疽组织。1个月和24个月时保肢的几率分别为95%和85%,患者存活几率分别为89%和64%。在A2组,1个月和24个月时保肢的几率分别仅为35%和17%,患者存活几率分别仅为64%和16%。在B组,58条肢体中有51条发生侵袭性感染;64%的病例中溃疡清创需要切除脚趾或部分足部。1个月和24个月时保肢的几率为98%和86%;患者存活几率为98%和68%。在决定是否需要血运重建方面,踝部和趾部收缩压不如反复的临床检查合适。
约80%有肢体威胁性缺血的患者和约95%有足部溃疡合并感染的患者可避免大截肢。多学科足部护理团队对复杂足部病变进行多因素治疗被认为是获得满意保肢效果的必要条件。