Bolger C, Bojanic S, Sheahan N F, Coakley D, Malone J F
Mercer's Institute for Research on Ageing, St. James's Hospital, Dublin, Ireland.
J Neuroophthalmol. 1999 Mar;19(1):42-5.
Ocular microtremor (OMT) is a high frequency tremor of the eyes present in all individuals. Recent reports suggest that OMT may be a useful indicator of brainstem function. However, the actual origin of ocular microtremor remains controversial. This study aims to provide evidence that OMT has a neurogenic origin.
The OMT activity of five subjects with unilateral oculomotor nerve palsy and one subject with complete unilateral internal and external ophthalmoplegia were recorded from both eyes of each subject using the piezoelectric strain gauge technique, with the normal eye acting as a control. Five parameters of OMT activity were studied in each subject: the peak count, the power of the high frequency peak, the percentage power between 60 and 100 Hz, the percentage power between 70 and 80 Hz, and the 10 dB cut-off point.
In the five subjects with oculomotor nerve palsy, the mean peak count in the normal eye was 88.4 Hz (SD+/-16.9) and in the affected eye was 59 Hz (SD+/-8.6), P < 0.0096. There was also a fall in the peak power, the power between 60 and 100 Hz, and the power between 70 and 80 Hz. In subject six, who had complete opthalmoplegia, there was no evidence of OMT activity in the denervated eye.
These results suggest that innervation of the extraocular muscles is necessary for normal OMT activity, and OMT therefore has a neurogenic origin.
眼球微震颤（OMT）是所有人都存在的一种高频眼球震颤。最近的报告表明，OMT可能是脑干功能的一个有用指标。然而，眼球微震颤的实际起源仍存在争议。本研究旨在提供证据证明OMT起源于神经源性。
使用压电应变仪技术记录了5名单侧动眼神经麻痹患者和1名完全性单侧内外直肌麻痹患者每只眼睛的OMT活动，以正常眼作为对照。研究了每位受试者OMT活动的五个参数：峰值计数、高频峰值功率、60至100赫兹之间的功率百分比、70至80赫兹之间的功率百分比以及10分贝截止点。
在5名动眼神经麻痹患者中，正常眼的平均峰值计数为88.4赫兹（标准差±16.9），患眼为59赫兹（标准差±8.6），P<0.0096。峰值功率、60至100赫兹之间的功率以及70至80赫兹之间的功率也有所下降。在第6名完全性眼肌麻痹患者中，失神经支配的眼睛没有OMT活动的证据。
这些结果表明，眼外肌的神经支配对于正常的OMT活动是必要的，因此OMT起源于神经源性。
