海洋双（吲哚）生物碱诺托品汀类似物双（3-吲哚基）噻唑的合成及其生物活性
Syntheses and biological activities of bis(3-indolyl)thiazoles, analogues of marine bis(indole)alkaloid nortopsentins.
作者信息
Gu X H, Wan X Z, Jiang B
机构信息
Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, P.R. China.
出版信息
Bioorg Med Chem Lett. 1999 Feb 22;9(4):569-72. doi: 10.1016/s0960-894x(99)00037-2.
Abstract
The thiazole analogues of the marine bis(indole)alkaloid nortopsentins, 2,4-bis(3-indolyl)thiazoles, were synthesized using Hantzsch reaction between indole-3-thioamides and 3-(alpha-bromoacetyl)indoles as the key step, and these analogues showed potent cytotoxic activities against a variety of human cancer cell lines in vitro.
摘要
海洋双（吲哚）生物碱诺托品汀的噻唑类似物，即2,4-双（3-吲哚基）噻唑，通过吲哚-3-硫代酰胺与3-（α-溴乙酰基）吲哚之间的汉茨施反应作为关键步骤合成，并且这些类似物在体外对多种人类癌细胞系显示出强大的细胞毒性活性。
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