Gu X H, Wan X Z, Jiang B
Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, P.R. China.
Bioorg Med Chem Lett. 1999 Feb 22;9(4):569-72. doi: 10.1016/s0960-894x(99)00037-2.
The thiazole analogues of the marine bis(indole)alkaloid nortopsentins, 2,4-bis(3-indolyl)thiazoles, were synthesized using Hantzsch reaction between indole-3-thioamides and 3-(alpha-bromoacetyl)indoles as the key step, and these analogues showed potent cytotoxic activities against a variety of human cancer cell lines in vitro.
海洋双（吲哚）生物碱诺托品汀的噻唑类似物，即2,4-双（3-吲哚基）噻唑，通过吲哚-3-硫代酰胺与3-（α-溴乙酰基）吲哚之间的汉茨施反应作为关键步骤合成，并且这些类似物在体外对多种人类癌细胞系显示出强大的细胞毒性活性。
