Synthesis and sar of 2- and 3-substituted 7-azaindoles as potential dopamine D4 ligands.
作者信息
Curtis N R, Kulagowski J J, Leeson P D, Ridgill M P, Emms F, Freedman S B, Patel S, Patel S
机构信息
Department of Medicinal Chemistry, Merck Sharp & Dohme Research Laboratories, Neuroscience Research Centre, Harlow, Essex, UK.
出版信息
Bioorg Med Chem Lett. 1999 Feb 22;9(4):585-8. doi: 10.1016/s0960-894x(99)00025-6.
Abstract
7-azaindole compounds bearing a cyclic amine moiety linked by a one or two carbon chain attached at the 2- or 3-position were synthesised and evaluated as potential dopamine D4 ligands. Highest affinity and selectivity for the D4 receptor resided in the 3-aminomethyl-7-azaindole series.
摘要
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