Synthesis and sar of 2- and 3-substituted 7-azaindoles as potential dopamine D4 ligands.

作者信息

Curtis N R, Kulagowski J J, Leeson P D, Ridgill M P, Emms F, Freedman S B, Patel S, Patel S

机构信息

Department of Medicinal Chemistry, Merck Sharp & Dohme Research Laboratories, Neuroscience Research Centre, Harlow, Essex, UK.

出版信息

Bioorg Med Chem Lett. 1999 Feb 22;9(4):585-8. doi: 10.1016/s0960-894x(99)00025-6.

DOI:10.1016/s0960-894x(99)00025-6

PMID:10098669

Abstract

7-azaindole compounds bearing a cyclic amine moiety linked by a one or two carbon chain attached at the 2- or 3-position were synthesised and evaluated as potential dopamine D4 ligands. Highest affinity and selectivity for the D4 receptor resided in the 3-aminomethyl-7-azaindole series.

摘要