Tokura Y
Department of Dermatology, Hamamatsu University School of Medicine, Japan.
J Dermatol Sci. 1999 Feb;19(2):114-22. doi: 10.1016/s0923-1811(98)00067-x.
Modulatory effects on cytokine expression of 8-MOP in conjunction with UVA have been investigated in different systems using different cell types, including keratinocytes, lymphocytes, monocytes and endothelial cells. The vast majority of data have exhibited reduced production of cytokines in 8-MOP/UVA-treated cells and skin, reflecting its simplistic cellular damage. However, 8-MOP/UVA at modest doses stimulate T lymphocytes to produce Thl cytokines such as interferon-gamma, suggesting that some activational events may occur in certain types of cells phototreated with 8-MOP. Both the inhibitory and augmentative effects of 8-MOP/UVA on cytokine production appear to participate in the mechanisms underlying the therapeutic efficacy of PUVA and extracorporeal photochemotherapy (photopheresis). In particular, photopheresis may exert beneficial effects on cutaneous T-cell lymphoma as a cytokine modifier.
在不同系统中，使用包括角质形成细胞、淋巴细胞、单核细胞和内皮细胞在内的不同细胞类型，研究了8-甲氧基补骨脂素（8-MOP）联合紫外线A（UVA）对细胞因子表达的调节作用。绝大多数数据显示，在8-MOP/UVA处理的细胞和皮肤中细胞因子产生减少，这反映了其简单的细胞损伤作用。然而，适度剂量的8-MOP/UVA可刺激T淋巴细胞产生γ干扰素等Th1细胞因子，这表明在用8-MOP进行光处理的某些类型细胞中可能会发生一些激活事件。8-MOP/UVA对细胞因子产生的抑制和增强作用似乎都参与了补骨脂素紫外线A光化学疗法（PUVA）和体外光化学疗法（光分离置换法）治疗效果的潜在机制。特别是，光分离置换法作为一种细胞因子调节剂，可能对皮肤T细胞淋巴瘤产生有益影响。
