Sato T, Tadokoro T, Sonoda T, Asada Y, Itami S, Takayasu S
Department of Dermatology, Oita Medical University, Japan.
J Dermatol Sci. 1999 Feb;19(2):123-5. doi: 10.1016/s0923-1811(98)00048-6.
Minoxidil is known to induce hair growth in male pattern baldness, for which development androgen plays a central role. We studied the effect of minoxidil on testosterone metabolism by cultured dermal papilla cells from balding or nonbalding scalp and dermal fibroblasts. In all three groups, 17beta-hydroxysteroid dehydrogenase activity was much higher than 5alpha-reductase activity. Minoxidil increased 17beta-hydroxysteroid dehydrogenase activity by nearly 40% (P < 0.001) in dermal papilla cells of balding scalp, whereas the effect was less marked in dermal papilla cells from nonbalding scalp and dermal fibroblasts. 5alpha-Reductase activity was also slightly increased by minoxidil in dermal papilla cells from balding scalp. Again, the effect on 5alpha-reductase activity was insignificant in the other two groups of cells. Whether such modification of testosterone metabolism in dermal papilla cells of balding scalp by minoxidil is related to its therapeutic effect remains unknown.
已知米诺地尔可促进男性型秃发患者头发生长，雄激素在该疾病发展过程中起核心作用。我们通过培养秃发或非秃发头皮的真皮乳头细胞以及真皮成纤维细胞，研究了米诺地尔对睾酮代谢的影响。在所有三组细胞中，17β-羟基类固醇脱氢酶活性均远高于5α-还原酶活性。米诺地尔使秃发头皮真皮乳头细胞中的17β-羟基类固醇脱氢酶活性增加了近40%（P < 0.001），而在非秃发头皮真皮乳头细胞和真皮成纤维细胞中的作用则不那么明显。米诺地尔也使秃发头皮真皮乳头细胞中的5α-还原酶活性略有增加。同样，在另外两组细胞中，米诺地尔对5α-还原酶活性的影响不显著。米诺地尔对秃发头皮真皮乳头细胞中睾酮代谢的这种改变是否与其治疗效果相关尚不清楚。
