Marek J, Páv J, Srámková J
Endokrinologie. 1976;68(3):300-8.
Thirty patients with active acromegaly were divided into five groups according to the results of their IRI and blood glucose curves in the course of oral glucose tolerance test. Young acromegalics with short duration of acromegaly had grossly exaggerated IRI response with the peak in the first half-an-hour and the flat blood glucose curve. In the second group the peak of IRI response was in the first hour and the blood glucose curve rose to high values in the early stage after the glucose load. The IRI response in the third group was still exaggerated but delayed and the diabetic type of blood glucose curve was found in some of these patients. Acromegalics with overt diabetes mellitus lost their exaggerated IRI response and the IRI curves were flat in those with more advanced disturbance of glucose tolerance. It was suggested that the groups described might represent individual stages in the development of diabetes mellitus in acromegaly. Unclear position in this scheme is kept by the group of active acromegalics with IRI response in normal limits and glucose tolerance unimpaired.
30例活动性肢端肥大症患者根据口服葡萄糖耐量试验过程中的胰岛素释放指数（IRI）和血糖曲线结果分为五组。病程短的年轻肢端肥大症患者IRI反应明显亢进，峰值出现在前半小时，血糖曲线平坦。第二组IRI反应峰值出现在第一小时，葡萄糖负荷后早期血糖曲线升至较高值。第三组IRI反应仍亢进但延迟，部分患者出现糖尿病型血糖曲线。显性糖尿病的肢端肥大症患者失去了亢进的IRI反应，在糖耐量障碍更严重的患者中IRI曲线平坦。提示所描述的这些组可能代表肢端肥大症患者糖尿病发展过程中的各个阶段。在该方案中，IRI反应正常且糖耐量未受损的活动性肢端肥大症患者组的情况尚不清楚。
