新生期用神经药物处理的大鼠出现永久性行为改变的进一步证据。
Further evidence of permanent behavioural changes in rats treated neonatally with neurodrugs.
作者信息
Dörner G
出版信息
Endokrinologie. 1976;68(3):345-8.
PMID:1009911
Abstract
Pargyline or reserpine treatment of male rats during the first two weeks of life resulted in significantly increased exploratory activity (sniffing) associated with a significantly decreased emotional reactivity (defecation rate) in adult life. These findings suggest that nonphysiological concentrations and/or turnover rates of neurotransmitters during brain differentiation apparently produced by neurodrugs can lead to permanent behavioural changes.
摘要
在出生后的前两周对雄性大鼠进行帕吉林或利血平治疗，结果显示成年后其探索活动（嗅探）显著增加，同时情绪反应性（排便率）显著降低。这些发现表明，在大脑分化过程中，神经药物明显产生的非生理浓度和/或神经递质周转率可能导致永久性的行为改变。
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