Franco M A, Greenberg H B
Instituto de Genetica, Facultad de Medicina, Pontifica UniversidadJaverina, Bogota, Columbia.
J Infect Dis. 1999 May;179 Suppl 3:S466-9. doi: 10.1086/314805.
Recent findings from our laboratory regarding the immune response of mice to rotavirus (a mucosal pathogen) show that although in most situations an acquired (T or B cell or both) response is necessary for elimination of primary rotavirus infection, unidentified innate mechanisms can also play a role in some mouse strains. Similar to what is seen with many other viruses, CD8+ T cells appear to provide the first but not the exclusive mechanism that mediates clearance of a primary rotavirus infection. Antibodies are the critical mediators of prevention against rotavirus reinfection. Nonneutralizing IgA monoclonal antibodies directed against VP6 (an internal structural rotavirus protein) can mediate immunity against rotaviruses in vivo. Rotavirus-specific CD8+ T cells can mediate their antiviral effect in the absence of perforin, fas, or interferon-gamma and are preferentially represented in the subset that expresses high levels of the enteric mucosal homing receptor alpha4beta7.
我们实验室最近关于小鼠对轮状病毒（一种黏膜病原体）免疫反应的研究结果表明，虽然在大多数情况下，获得性（T细胞或B细胞或两者）反应对于消除原发性轮状病毒感染是必要的，但在某些小鼠品系中，未知的先天机制也可发挥作用。与许多其他病毒的情况类似，CD8 + T细胞似乎是介导原发性轮状病毒感染清除的首要但并非唯一机制。抗体是预防轮状病毒再次感染的关键介质。针对VP6（一种轮状病毒内部结构蛋白）的非中和性IgA单克隆抗体可在体内介导针对轮状病毒的免疫。轮状病毒特异性CD8 + T细胞可在缺乏穿孔素、Fas或干扰素 - γ的情况下介导其抗病毒作用，并且在表达高水平肠道黏膜归巢受体α4β7的亚群中优先存在。
