Gayo L M
Department of Medicinal Chemistry, Signal Pharmaceuticals, Inc., 5555 Oberlin Drive, San Diego, California 92121, USA.
Biotechnol Bioeng. 1998 Spring;61(2):95-106.
Solution-phase high throughput synthesis has emerged as a powerful method for the rapid generation of chemical libraries. The success of this approach is largely due to the development of novel synthetic methodologies that expedite the preparation of compounds. Several isolation/purification techniques have also been developed to eliminate the time-consuming purification procedures often associated with solution-phase chemistry. These methods are amenable to parallel synthesis and combinatorial strategies and can be fully automated. In addition, the compound libraries generated using solution-phase high throughput synthesis have been used to accelerate both lead identification and lead optimization programs at various companies.
溶液相高通量合成已成为快速生成化学文库的一种强大方法。这种方法的成功很大程度上归功于新型合成方法的发展，这些方法加快了化合物的制备。还开发了几种分离/纯化技术，以消除通常与溶液相化学相关的耗时纯化程序。这些方法适用于平行合成和组合策略，并且可以完全自动化。此外，使用溶液相高通量合成生成的化合物文库已被用于加速各公司的先导化合物识别和先导化合物优化计划。
