Aggarwal N, Sawhney H, Vasishta K, Chopra S, Bambery P
Department of Obstetrics and Gynaecology, Nehru Hospital, Chandigarh, India.
Aust N Z J Obstet Gynaecol. 1999 Feb;39(1):28-30. doi: 10.1111/j.1479-828x.1999.tb03438.x.
We reviewed the obstetrical performance and outcome of 15 pregnancies in patients with systemic lupus erythematosus (SLE) (study group) and compared them with 45 age and parity-matched normal pregnancies (control group). Eleven women (73.8%) were in remission phase and 4 (26.7%) had active disease at the time of conception. The time interval between disease diagnosis and the index pregnancy was 4.2 +/- 2.5 years. Two patients with renal involvement had lupus flare-up during the antenatal period. There was no case of lupus flare-up in the postpartum period. Gestational age at delivery was significantly lower in SLE patients (35.9 +/- 2.5 weeks) compared to the control group (37.4 +/- 2.2 weeks). The incidence of intrauterine growth retardation was significantly higher in the SLE patients (40%). There was no case of neonatal lupus or congenital heart block.
我们回顾了15例系统性红斑狼疮（SLE）患者妊娠的产科表现及结局（研究组），并将其与45例年龄和胎次匹配的正常妊娠（对照组）进行比较。11名女性（73.8%）在受孕时处于缓解期，4名（26.7%）患有活动性疾病。疾病诊断与本次妊娠之间的时间间隔为4.2±2.5年。2例有肾脏受累的患者在孕期出现狼疮病情加重。产后无狼疮病情加重病例。SLE患者的分娩孕周（35.9±2.5周）显著低于对照组（37.4±2.2周）。SLE患者的宫内生长受限发生率显著更高（40%）。无新生儿狼疮或先天性心脏传导阻滞病例。
