Hunt S C, Province M A, Atwood L D, Sholinsky P, Lalouel J M, Rao D C, Williams R R, Leppert M F
Department of Internal Medicine, University of Utah, Salt Lake City, USA.
J Hypertens. 1999 Jan;17(1):39-43. doi: 10.1097/00004872-199917010-00007.
A previous study has shown significant linkage of five markers near the lipoprotein lipase locus to systolic blood pressure, but not to diastolic blood pressure, in nondiabetic members of 48 Taiwanese families selected for noninsulin-dependent diabetes. However, lipoprotein lipase markers did not appear strongly linked to systolic blood pressure in a study of Mexican-Americans using a variety of selection schemes. The objective of the current study was to test whether markers near the lipoprotein lipase gene were linked to hypertension in Caucasians.
To test for linkage of genetic markers in or near the lipoprotein lipase gene to hypertension in Caucasians, two sets of Caucasian hypertensive sibships were genotyped. The samples included 261 sibships (431 effective sibpairs) from four field centers of the National Heart, Lung and Blood Institute Family Heart Study and 211 sibships (282 effective sibpairs) from the Health Family Tree database in Utah.
Two highly polymorphic markers in or near the lipoprotein lipase gene showed no evidence of excess allele sharing in either set of hypertensive sibships. Combining the two datasets resulted in 653 and 713 effective sibpairs for the two markers, sharing 0.495 +/- 0.30 and 0.486 +/- 0.28 alleles identical by descent compared to an expected sharing of 0.50. Multipoint analysis of the two loci also did not show linkage (P = 0.95).
We conclude that the lipoprotein lipase locus and nearby regions do not appear to be linked to hypertension in Caucasians.
先前一项研究表明，在因非胰岛素依赖型糖尿病而入选的48个台湾家庭的非糖尿病成员中，脂蛋白脂肪酶基因座附近的5个标记与收缩压显著相关，但与舒张压无关。然而，在一项针对墨西哥裔美国人的研究中，采用了多种选择方案，脂蛋白脂肪酶标记与收缩压之间并未表现出强烈的关联。本研究的目的是检验脂蛋白脂肪酶基因附近的标记与高加索人高血压是否相关。
为了检验脂蛋白脂肪酶基因内或附近的遗传标记与高加索人高血压的关联性，对两组高加索高血压同胞对进行了基因分型。样本包括来自国立心肺血液研究所家族心脏研究4个现场中心的261个同胞对（431个有效同胞对），以及来自犹他州健康家族树数据库的211个同胞对（282个有效同胞对）。
脂蛋白脂肪酶基因内或附近的两个高度多态性标记在任何一组高血压同胞对中均未显示出等位基因共享过多的证据。将两个数据集合并后，这两个标记分别有653个和713个有效同胞对，其通过血缘相同的等位基因共享率分别为0.495±0.30和0.486±0.28，而预期共享率为0.50。对这两个基因座的多点分析也未显示出关联性（P = 0.95）。
我们得出结论，在高加索人中，脂蛋白脂肪酶基因座及附近区域似乎与高血压无关。
