Gasco M R
Farmaco Sci. 1976 Nov;31(11):817-23.
Folic acid and pteroylaspartic acid form solid complexes with N-dialkylaminoalylphenothiazines and with N-dialkylaminoalkylphenoxazines. Folic acid forms 1:2 solid complexes with derivatives having the amine nitrogen in gamma position to heterocyclic nitrogen; the complexes are not formed with those derivatives in which the amine nitrogen is in the beta position to the heterocyclic nitrogen. Pteroylaspartic acid forms 1: 1 solid complexes with classes of compounds having aminic nitrogen in both gamma or beta position to the heterocyclic nitrogen.
叶酸和蝶酰天冬氨酸与N - 二烷基氨基丙基吩噻嗪以及N - 二烷基氨基烷基吩恶嗪形成固体配合物。叶酸与胺氮处于杂环氮γ位的衍生物形成1:2固体配合物;而与胺氮处于杂环氮β位的那些衍生物则不形成配合物。蝶酰天冬氨酸与胺氮处于杂环氮γ位或β位的各类化合物形成1:1固体配合物。