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[蝶啶与吩噻嗪和吩恶嗪衍生物的复合物]

[Complexes of pteridines with phenothiazine and phenoxazine derivatives].

作者信息

Gasco M R

出版信息

Farmaco Sci. 1976 Nov;31(11):817-23.

PMID:1010033
Abstract

Folic acid and pteroylaspartic acid form solid complexes with N-dialkylaminoalylphenothiazines and with N-dialkylaminoalkylphenoxazines. Folic acid forms 1:2 solid complexes with derivatives having the amine nitrogen in gamma position to heterocyclic nitrogen; the complexes are not formed with those derivatives in which the amine nitrogen is in the beta position to the heterocyclic nitrogen. Pteroylaspartic acid forms 1: 1 solid complexes with classes of compounds having aminic nitrogen in both gamma or beta position to the heterocyclic nitrogen.

摘要

叶酸和蝶酰天冬氨酸与N - 二烷基氨基丙基吩噻嗪以及N - 二烷基氨基烷基吩恶嗪形成固体配合物。叶酸与胺氮处于杂环氮γ位的衍生物形成1:2固体配合物;而与胺氮处于杂环氮β位的那些衍生物则不形成配合物。蝶酰天冬氨酸与胺氮处于杂环氮γ位或β位的各类化合物形成1:1固体配合物。

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