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[阿米巴病的胸膜肺部表现]

[Pleuropulmonary manifestations of amebiasis].

作者信息

Mbaye P S, Koffi N, Camara P, Burgel P R, Hovette P, Klotz F

机构信息

Service Médicaux, Hôpital Principal de Dakar, Sénégal.

出版信息

Rev Pneumol Clin. 1998 Dec;54(6):346-52.

Abstract

Amibiasis is the third leading cause of death due to parasitic infections in the world. Amibiasis is endemic in the warm regions of the world with deficient hygiene and socio-economic situations. Entamoeba histolytica is the causal agent of invasive amibiasis, unlike Entamoeba dispar which is not a pathogen for humans. Amibian colitis and amibian abscess of the liver are the most frequent intestinal and extra-intestinal manifestations. Pleuropulmonary complications almost always occur in patients with a liver abscess, the intrathoracic contamination via transphrenic dissemination predominating. Respiratory signs are inaugural in 80% of the cases. Pleuropulmonary ambiasis designates the localization of the amibian infestation, but the clinical expression may vary: pneumonia, lung abscess, pleurisy, hepatobronchial fistulization and more infrequently pulmonary embolism. The preferential localization is the right hemithorax related to abscess in the right lobe of the liver. Left lobe abscesses lead to left-sided pleuropulmonary complications with the risk of rupture into the pericardium. Chocolate-colored pus from a pleural or abscess puncture or vomitus strongly suggests the diagnosis, which is confirmed by highly-positive serology. Metronidazole is the treatment of choice, providing cure without sequellae. In Africa, mortality and morbidity due to ambiasis are high. In Abidjan, 92% of cured patients have sequella, and mortality reaches 15%, the consequence of late diagnosis.

摘要

阿米巴病是全球因寄生虫感染导致死亡的第三大主要原因。在卫生条件差和社会经济状况不佳的世界温暖地区,阿米巴病呈地方性流行。溶组织内阿米巴是侵袭性阿米巴病的病原体,而迪斯帕内阿米巴则不是人类病原体。阿米巴性结肠炎和阿米巴性肝脓肿是最常见的肠道和肠道外表现。胸膜肺并发症几乎总是发生在肝脓肿患者中,经膈传播导致胸腔内感染占主导。80%的病例以呼吸道症状为首发表现。胸膜肺阿米巴病指的是阿米巴感染的部位,但临床表现可能有所不同:肺炎、肺脓肿、胸膜炎、肝支气管瘘,较少见的还有肺栓塞。由于肝右叶脓肿,病变多优先累及右半胸。肝左叶脓肿会导致左侧胸膜肺并发症,并有破入心包的风险。胸膜或脓肿穿刺抽出的巧克力色脓液或呕吐物强烈提示诊断,高度阳性的血清学检查可确诊。甲硝唑是首选治疗药物,可治愈且无后遗症。在非洲,阿米巴病导致的死亡率和发病率都很高。在阿比让,92%的治愈患者有后遗症,死亡率达15%,这是诊断延误的后果。

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