Cianti C
Divisione di Medicina Interna, Day-Hospital Oncologico, Roma, Italia.
Clin Ter. 1998 Nov-Dec;149(6):439-46.
To present an approach to the treatment of primary and metastatic breast cancer in the elderly.
A large number of studies in elderly women with breast cancer have been reviewed.
The studies reviewed demonstrate that the annual incidence of breast cancer increases with age, along with a longer life expectancy. Biennial mammography and annual physical examination are effective, but compliance with screening recommendations decreases with age. Most treatment decisions are based on studies that seldom include women over 65 years of age. With the exception of specific comorbid conditions that preclude anesthesia and surgery, older women tolerate breast surgery as well as younger women. Tamoxifen is the usual adjuvant systemic therapy given to older women. Metastatic breast cancer older women, in generally good condition, tolerate standard doses of chemotherapy as well as their younger counterparts.
Future research should include clinical trials designed specifically for the elderly taking into account functional status and quality of life.
介绍一种治疗老年原发性和转移性乳腺癌的方法。
回顾了大量针对老年乳腺癌女性的研究。
所回顾的研究表明，乳腺癌的年发病率随年龄增长而增加，同时预期寿命延长。两年一次的乳房X线摄影和每年一次的体格检查是有效的，但对筛查建议的依从性随年龄下降。大多数治疗决策基于很少纳入65岁以上女性的研究。除了排除麻醉和手术的特定合并症外，老年女性耐受乳房手术的情况与年轻女性相同。他莫昔芬是给予老年女性的常用辅助全身治疗药物。一般状况良好的老年转移性乳腺癌女性耐受标准剂量化疗的情况与年轻女性相同。
未来的研究应包括专门针对老年人设计的临床试验，同时考虑功能状态和生活质量。
