Kimmick G, Muss H B
Comprehensive Cancer Center of Wake Forest University, Bowman Gray School of Medicine, Winston-Salem, North Carolina 27157, USA.
Clin Geriatr Med. 1997 May;13(2):265-82.
More than 50% of breast cancers are diagnosed in women aged 65 years or older, a quickly growing segment of the population. Healthy older women should be offered state-of-the-art screening and treatment for breast cancer, including mammography, surgery, radiation therapy, and adjuvant therapy for early stage tumors. Clinical trials focusing on the role of adjuvant treatment in older women with breast cancer are of chief importance. The optimal treatment for older women with life-threatening, comorbid conditions may be primary treatment with tamoxifen or adjuvant therapy with tamoxifen alone after definitive surgery. Outside the clinical trials setting, metastatic disease should be treated similarly in all age groups.
超过50%的乳腺癌在65岁及以上的女性中被诊断出来，这是一个快速增长的人群细分群体。健康的老年女性应接受乳腺癌的先进筛查和治疗，包括乳房X光检查、手术、放射治疗以及早期肿瘤的辅助治疗。聚焦辅助治疗在老年乳腺癌女性中作用的临床试验至关重要。对于患有危及生命的合并症的老年女性，最佳治疗可能是他莫昔芬的初始治疗或在确定性手术后单独使用他莫昔芬的辅助治疗。在临床试验环境之外，转移性疾病在所有年龄组中的治疗方式应相似。
