• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

与大剂量化疗及自体干细胞救援相关的水痘带状疱疹病毒感染

Varicella zoster virus infection associated with high-dose chemotherapy and autologous stem-cell rescue.

作者信息

Bilgrami S, Chakraborty N G, Rodriguez-Pinero F, Khan A M, Feingold J M, Bona R D, Edwards R L, Dorsky D, Clive J, Mukherji B, Tutschka P J

机构信息

Bone Marrow Transplant Program, University of Connecticut Health Center, Farmington 06030, USA.

出版信息

Bone Marrow Transplant. 1999 Mar;23(5):469-74. doi: 10.1038/sj.bmt.1701594.

DOI:10.1038/sj.bmt.1701594
PMID:10100561
Abstract

A retrospective evaluation of 215 consecutive recipients of high-dose chemotherapy (HDC) and autologous stem cell rescue (ASCR) was conducted to ascertain the incidence, temporal course, and outcome of varicella zoster virus (VZV) infection. Herpes zoster was identified in 40 individuals at a median of 69 days following ASCR. Six of these cases occurred at a median of 33 days prior to ASCR but following the initiation of high doses of stem cell mobilization chemotherapy. Twenty-five percent of patients demonstrated cutaneous or systemic dissemination and 32.5% required medical intervention for post-herpetic neuralgia. All except two individuals received antiviral chemotherapy. One patient with active VZV infection died of multiorgan failure 39 days after ASCR. Multivariate analysis of risk factors disclosed the significance of prophylactic acyclovir use in Herpes simplex virus seropositive individuals in reducing the risk of VZV infection. Moreover, the use of busulfan, thiotepa and carboplatin as the conditioning chemotherapy regimen was associated with an increased risk of subsequent VZV infection. The incidence of VZV reactivation after HDC and ASCR is similar to that observed following bone marrow transplantation but has an earlier onset. This may be related to an earlier induction of immunosuppression by stem cell mobilization chemotherapy administered prior to ASCR. We demonstrated a marked reduction in the proliferative and synthetic capacities of peripheral blood mononuclear cells obtained prior to and following stem cell mobilizing chemotherapy. Moreover, greater than 80% of VZV infections occurred within 6 months following ASCR and late cases were seldom observed compared to allogeneic and autologous bone marrow transplantation. The role of antiviral chemoprophylaxis during the period of maximum immunocompromise needs to be studied further in the HDC-ASCR setting.

摘要

对215例连续接受大剂量化疗(HDC)及自体干细胞救援(ASCR)的患者进行回顾性评估,以确定水痘带状疱疹病毒(VZV)感染的发生率、时间进程及转归。40例患者在ASCR后中位时间69天被诊断为带状疱疹。其中6例发生在ASCR前中位时间33天,但在开始大剂量干细胞动员化疗之后。25%的患者出现皮肤或全身播散,32.5%的患者因疱疹后神经痛需要医学干预。除2例患者外,所有患者均接受了抗病毒化疗。1例活动性VZV感染患者在ASCR后39天死于多器官功能衰竭。多因素风险分析显示,单纯疱疹病毒血清学阳性个体使用预防性阿昔洛韦可降低VZV感染风险。此外,使用白消安、噻替派和卡铂作为预处理化疗方案与后续VZV感染风险增加相关。HDC及ASCR后VZV再激活的发生率与骨髓移植后观察到的相似,但发病更早。这可能与ASCR前给予的干细胞动员化疗更早诱导免疫抑制有关。我们发现干细胞动员化疗前后获取的外周血单个核细胞的增殖及合成能力显著降低。此外,超过80%的VZV感染发生在ASCR后6个月内,与异基因及自体骨髓移植相比,晚期病例很少见。在HDC-ASCR背景下,最大免疫抑制期抗病毒化学预防的作用需要进一步研究。

相似文献

1
Varicella zoster virus infection associated with high-dose chemotherapy and autologous stem-cell rescue.与大剂量化疗及自体干细胞救援相关的水痘带状疱疹病毒感染
Bone Marrow Transplant. 1999 Mar;23(5):469-74. doi: 10.1038/sj.bmt.1701594.
2
Factors influencing varicella zoster virus infection after allogeneic peripheral blood stem cell transplantation: low-dose acyclovir prophylaxis and pre-transplant diagnosis of lymphoproliferative disorders.异基因外周血干细胞移植后影响水痘带状疱疹病毒感染的因素:低剂量阿昔洛韦预防及移植前淋巴增殖性疾病的诊断
Transpl Infect Dis. 2008 Apr;10(2):90-8. doi: 10.1111/j.1399-3062.2007.00247.x. Epub 2007 Jul 1.
3
Incidence, risk factors and outcome of varicella-zoster virus infection in children after haematopoietic stem cell transplantation.造血干细胞移植后儿童水痘-带状疱疹病毒感染的发病率、危险因素及预后
Bone Marrow Transplant. 2000 Jan;25(2):167-72. doi: 10.1038/sj.bmt.1702119.
4
Clinical efficacy of prophylactic strategy of long-term low-dose acyclovir for Varicella-Zoster virus infection after allogeneic peripheral blood stem cell transplantation.长期小剂量阿昔洛韦预防策略对异基因外周血干细胞移植后水痘-带状疱疹病毒感染的临床疗效
Clin Transplant. 2008 Nov-Dec;22(6):770-9. doi: 10.1111/j.1399-0012.2008.00877.x. Epub 2008 Aug 13.
5
Evaluation of infectious complications and immune recovery following high-dose chemotherapy (HDC) and autologous peripheral blood progenitor cell transplantation (PBPC-T) in 148 breast cancer patients.148例乳腺癌患者大剂量化疗(HDC)及自体外周血祖细胞移植(PBPC-T)后感染并发症及免疫恢复情况的评估
Anticancer Res. 2002 Nov-Dec;22(6B):3701-8.
6
[Analysis of varicella zoster virus infection following allogeneic stem cell transplants].[异基因造血干细胞移植后水痘带状疱疹病毒感染的分析]
Rinsho Ketsueki. 2004 Oct;45(10):1090-4.
7
Varicella zoster infection after bone marrow transplantation: incidence, risk factors and complications.骨髓移植后的水痘带状疱疹感染:发病率、危险因素及并发症
Bone Marrow Transplant. 1994 Mar;13(3):277-83.
8
Varicella-zoster virus infections after autologous bone marrow transplantation in children.儿童自体骨髓移植后的水痘-带状疱疹病毒感染
Bone Marrow Transplant. 1989 Mar;4(2):191-4.
9
Long-term acyclovir prophylaxis for prevention of varicella zoster virus infection after autologous blood stem cell transplantation in patients with acute leukemia.长期使用阿昔洛韦预防急性白血病患者自体造血干细胞移植后水痘带状疱疹病毒感染。
Bone Marrow Transplant. 1992 Dec;10(6):495-8.
10
Incidence and risk of postherpetic neuralgia after varicella zoster virus infection in hematopoietic cell transplantation recipients: Hokkaido Hematology Study Group.造血细胞移植受者水痘带状疱疹病毒感染后带状疱疹后神经痛的发病率及风险:北海道血液学研究组
Biol Blood Marrow Transplant. 2009 Jun;15(6):724-9. doi: 10.1016/j.bbmt.2009.03.003.

引用本文的文献

1
Incidence and time trends of herpes zoster among patients with head and neck cancer who did and did not undergo radiotherapy: A population-based cohort study.未行放疗与行放疗的头颈部癌症患者中带状疱疹的发病率及时间趋势:一项基于人群的队列研究。
PLoS One. 2021 May 20;16(5):e0250724. doi: 10.1371/journal.pone.0250724. eCollection 2021.
2
Radiotherapy combined with chemotherapy increases the risk of herpes zoster in patients with gynecological cancers: a nationwide cohort study.放疗联合化疗增加妇科癌症患者带状疱疹风险:一项全国性队列研究。
J Gynecol Oncol. 2021 Mar;32(2):e13. doi: 10.3802/jgo.2021.32.e13. Epub 2020 Dec 2.
3
Herpes Zoster Risk in Immunocompromised Adults in the United States: A Systematic Review.
美国免疫功能低下成年人带状疱疹的风险:系统评价。
Clin Infect Dis. 2020 Oct 23;71(7):e125-e134. doi: 10.1093/cid/ciz1090.
4
Infectious Complications during Tandem High-Dose Chemotherapy and Autologous Stem Cell Transplantation for Children with High-Risk or Recurrent Solid Tumors.高危或复发性实体瘤儿童接受串联大剂量化疗和自体干细胞移植期间的感染性并发症
PLoS One. 2016 Sep 14;11(9):e0162178. doi: 10.1371/journal.pone.0162178. eCollection 2016.
5
Varicella zoster virus reactivation after autologous SCT is a frequent event and associated with favorable outcome in myeloma patients.自体造血干细胞移植后水痘带状疱疹病毒再激活是骨髓瘤患者中的常见事件,且与良好预后相关。
Bone Marrow Transplant. 2015 Apr;50(4):573-8. doi: 10.1038/bmt.2014.290. Epub 2015 Jan 19.
6
T cells increase before zoster and PD-1 expression increases at the time of zoster in immunosuppressed nonhuman primates latently infected with simian varicella virus.在潜伏感染猿猴水痘病毒的免疫抑制非人灵长类动物中,T细胞在带状疱疹出现前增加,且PD -1表达在带状疱疹发作时升高。
J Neurovirol. 2014 Jun;20(3):309-13. doi: 10.1007/s13365-014-0237-7. Epub 2014 Feb 19.
7
Long-term acyclovir for prevention of varicella zoster virus disease after allogeneic hematopoietic cell transplantation--a randomized double-blind placebo-controlled study.长期使用阿昔洛韦预防异基因造血细胞移植后的水痘带状疱疹病毒病——一项随机双盲安慰剂对照研究
Blood. 2006 Mar 1;107(5):1800-5. doi: 10.1182/blood-2005-09-3624. Epub 2005 Nov 10.