泛醌-3与磷脂膜的相互作用。

The interaction of ubiquinone-3 with phospholipid membranes.

作者信息

Asai Y, Watanabe S

机构信息

Formulation Research Laboratory, Kawashima, Eisai Co., Ltd., Hashima-gun, Gifu, Japan.

出版信息

FEBS Lett. 1999 Mar 5;446(1):169-72. doi: 10.1016/s0014-5793(99)00203-3.

DOI:10.1016/s0014-5793(99)00203-3

PMID:10100636

Abstract

The effects of ubiquinone-3 (UQ) on dipalmitoylphosphatidylcholine (DPPC) membrane were studied by surface monolayer, differential scanning calorimetry (DSC) and fluorescence techniques. DPPC and UQ are proved to be freely miscible in the mixed monolayer at an air/water interface, and to be partially miscible in bulk phase, i.e. bilayer and solid phase. There is a condensing interaction between UQ and DPPC in the UQ/DPPC mixed monolayers. The solubility of UQ in the DPPC is about 20 mole% and the solubility of DPPC in UQ is about 10 mole%. The membrane fluidity of DPPC was increased by the addition of UQ and the phase transition temperature was decreased.

摘要

通过表面单层、差示扫描量热法（DSC）和荧光技术研究了泛醌-3（UQ）对二棕榈酰磷脂酰胆碱（DPPC）膜的影响。结果表明，在空气/水界面的混合单层中，DPPC和UQ可自由混溶，而在本体相（即双层和固相）中则部分混溶。在UQ/DPPC混合单层中，UQ与DPPC之间存在凝聚相互作用。UQ在DPPC中的溶解度约为20摩尔%，DPPC在UQ中的溶解度约为10摩尔%。添加UQ可提高DPPC的膜流动性，并降低相变温度。