Suppr超能文献

使用高能铒:钇铝石榴石激光进行眶周皮肤表面重塑:50例患者的结果

Periorbital skin resurfacing using high energy erbium:YAG laser: results in 50 patients.

作者信息

Weiss R A, Harrington A C, Pfau R C, Weiss M A, Marwaha S

机构信息

Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

出版信息

Lasers Surg Med. 1999;24(2):81-6. doi: 10.1002/(sici)1096-9101(1999)24:2<81::aid-lsm2>3.0.co;2-9.

Abstract

OBJECTIVE

To evaluate Erbium:YAG regional periorbital laser resurfacing clinically and histologically.

STUDY DESIGN/MATERIALS AND METHODS: Photographic evaluation before and after Erbium:YAG resurfacing with histologic evaluation of depth of injury.

SETTING

Group private single specialty practice.

PATIENTS

Fifty patients in the age range of 35-62 years, Fitzpatrick skin types I-III were treated using Erbium:YAG for regional resurfacing of periorbital rhytides.

OUTCOME MEASURES

Patients were seen at days 1, 2, 3, 7, 14, 28, and at six months and one year. Photographs were obtained prior to application of topical anesthesia and were utilized to judge improvement of rhytides at all time intervals. Additional photographs were taken at each follow-up visit and the results judged by an independent investigator. Results were graded into five categories at all treatment intervals: no improvement, mild (grade 1: up to 25%), moderate (grade 2: 25-50%), good (grade 3: 50-75%, or excellent (grade 4: 75-100%). For histologic evaluation of depth of ablation and thermal injury one, two, and three passes at 21.2 J/cm2 were performed on four patients.

RESULTS

Re-epithelization in the periorbital region was rapid with a mean duration of 2.65 days. Erythema ranged from a longest of six weeks to the shortest of seven days with a mean duration of 15.4 days. Evaluation of clinical results revealed that at two weeks mean improvement was 2.15 (between moderate and good). At four weeks further improvement was noted with a mean of 2.62. By six months, mean improvement score increased to 2.94. Minimal further improvement was noted between six months and one year with a mean improvement score of 3.02 (good to excellent). Histology revealed complete removal of the epidermis with one to three passes. Dermal ablation of 5-10 microns accompanied by small increases (5-10 microns) in dermal thermal injury occurred with each subsequent pass.

CONCLUSIONS

We conclude that high energy Erbium:YAG periorbital resurfacing is a safe and effective modality which achieves substantial therapeutic effect. Most patients achieve approximately 75% improvement. Erythema fades quickly, reepithelization is rapid and side effects are minimal.

摘要

目的

从临床和组织学角度评估铒激光对眶周区域进行激光表面重塑的效果。

研究设计/材料与方法:通过铒激光表面重塑前后的照片评估以及对损伤深度的组织学评估。

研究地点

私人单专科诊所。

患者

50名年龄在35 - 62岁之间、菲茨帕特里克皮肤分型为I - III型的患者,使用铒激光对眶周皱纹进行区域表面重塑治疗。

观察指标

在第1、2、3、7、14、28天以及6个月和1年时对患者进行观察。在局部麻醉前拍摄照片,用于判断各时间段皱纹的改善情况。每次随访时拍摄额外照片,由独立研究者判断结果。在所有治疗时间段,结果分为五类:无改善、轻度(1级:改善达25%)、中度(2级:改善25% - 50%)、良好(3级:改善50% - 75%)或优秀(4级:改善75% - 100%)。对4名患者在能量为21.2 J/cm²时进行1次、2次和3次照射,以进行消融深度和热损伤的组织学评估。

结果

眶周区域的上皮再形成迅速,平均持续时间为2.65天。红斑持续时间最长为6周,最短为7天,平均持续时间为15.4天。临床结果评估显示,两周时平均改善程度为2.15(介于中度和良好之间)。四周时进一步改善,平均为2.62。到6个月时,平均改善评分增至2.94。6个月至1年期间改善程度进一步轻微增加,平均改善评分为3.02(良好至优秀)。组织学显示,照射1 - 3次可完全去除表皮。每次后续照射会导致5 - 10微米的真皮消融,并伴有真皮热损伤轻微增加(5 - 10微米)。

结论

我们得出结论,高能量铒激光眶周表面重塑是一种安全有效的治疗方式,能取得显著治疗效果。大多数患者改善程度约达75%。红斑消退迅速,上皮再形成快,副作用极小。

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验