Anderson R B, Key B
Neurodevelopment Laboratory, Department of Anatomy and Cell Biology, University of Melbourne, Parkville 3052, Australia.
Development. 1999 May;126(9):1859-68. doi: 10.1242/dev.126.9.1859.
A scaffold of axons consisting of a pair of longitudinal tracts and several commissures is established during early development of the vertebrate brain. We report here that NOC-2, a cell surface carbohydrate, is selectively expressed by a subpopulation of growing axons in this scaffold in Xenopus. NOC-2 is present on two glycoproteins, one of which is a novel glycoform of the neural cell adhesion molecule N-CAM. When the function of NOC-2 was perturbed using either soluble carbohydrates or anti-NOC-2 antibodies, axons expressing NOC-2 exhibited aberrant growth at specific points in their pathway. NOC-2 is the first-identified axon guidance molecule essential for development of the axon scaffold in the embryonic vertebrate brain.
在脊椎动物大脑的早期发育过程中，会形成一个由一对纵向束和几个连合组成的轴突支架。我们在此报告，NOC-2是一种细胞表面碳水化合物，在非洲爪蟾的这种支架中，它由一群正在生长的轴突选择性表达。NOC-2存在于两种糖蛋白上，其中一种是神经细胞黏附分子N-CAM的一种新型糖型。当使用可溶性碳水化合物或抗NOC-2抗体干扰NOC-2的功能时，表达NOC-2的轴突在其路径的特定点表现出异常生长。NOC-2是首个被鉴定出的对胚胎脊椎动物大脑中轴突支架发育至关重要的轴突导向分子。
