Cvijić G, Janić-Sibalić V, Demajo M, Karakasević A, Petrović V M, Ivanisević-Milovanović O K
Institute of Physiology and Biochemistry, Faculty of Biology, University of Beograd, Yugoslavia.
Acta Physiol Hung. 1997;85(3):269-76.
For assessing monoamine oxidase (MAO-A and -B) activities in the hypothalamus, ovaries and uterus, mature female rats were exposed to either continuous light or dark over 6 weeks. Confirming previous studies, continuous light induced constant estrus in all animals. The majority of animals kept under continuous dark during the six weeks remained mostly in diestrus with estrus appearing sporadically. The endocrinological function of the ovaries was disturbed by continuous light, which resulted in the development of polycystic ovaries, their morphological appearance being not significantly affected by continuous dark. Hypothalamic MAO-A activity was markedly reduced under the influence of both light (p < 0.05) and dark (p < 0.01). The activity of hypothalamic MAO-B was reduced only under the influence of dark (p < 0.01). In the ovaries, no significant differences were detected in either MAO-A or -B activity as a result of these environmental manipulations. In the uterus of rats exposed to continuous light which developed polycystic ovaries, MAO-A activity was significantly lower (p < 0.05) in comparison to either intact controls or rats exposed to continuous dark. These results demonstrate that chronic changes in photoperiodicity may considerably influence MAO-A activity and to a lesser extent MAO-B activity dependent on the tissue studied.
为评估下丘脑、卵巢和子宫中的单胺氧化酶（MAO-A和MAO-B）活性，将成年雌性大鼠在6周内置于持续光照或黑暗环境中。与先前的研究一致，持续光照使所有动物持续处于发情期。在六周的持续黑暗环境下饲养的大多数动物大多处于间情期，偶尔出现发情期。持续光照会扰乱卵巢的内分泌功能，导致多囊卵巢的形成，而持续黑暗对其形态外观没有显著影响。下丘脑MAO-A活性在光照（p < 0.05）和黑暗（p < 0.01）的影响下均显著降低。下丘脑MAO-B活性仅在黑暗影响下降低（p < 0.01）。在卵巢中，这些环境处理对MAO-A或MAO-B活性均未检测到显著差异。在因持续光照而出现多囊卵巢的大鼠子宫中，与完整对照组或持续黑暗环境下的大鼠相比，MAO-A活性显著降低（p < 0.05）。这些结果表明，光周期的长期变化可能会极大地影响MAO-A活性，并在较小程度上影响MAO-B活性，具体取决于所研究的组织。
