Esposito G, Tempesta A, Galati M G, de Bellis M, Rossi G B, Potena M I, Marone P, Daniele B, Del Vecchio S
Ria Laboratory of Nuclear Medicine, National Cancer Institute, Naples, Italy.
Cancer Detect Prev. 1999;23(2):116-22. doi: 10.1046/j.1525-1500.1999.09905.x.
Sixty-eight patients (45 males, 23 females) were studied in order to assess the usefulness of mucosal tissue concentrations of both carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) in detecting patients at high risk for gastric cancer. CEA and CA19-9 were assayed on cytosol obtained from multiple endoscopic biopsies of 41 patients with chronic superficial gastritis, 18 with chronic atrophic gastritis, and 9 with gastric cancer. Mucosal tissue concentrations of both CEA and CA19-9 increased from chronic superficial gastritis to chronic atrophic gastritis and to gastric cancer (p = 0.005 and p = 0.002, respectively). Mucosal CEA levels in patients with intestinal metaplasia (IM) were significantly higher than in nonmetaplastic mucosa (p = 0.04). Epithelial dysplasia was associated with higher, though not significant, tissue concentrations of both CEA and CA19-9 when compared with IM. Finally, a correlation between serum levels and tissue concentrations was observed only for CA19-9 (Pearson's correlation coefficient = 0.7). In conclusion, these data indicate that gastric mucosa of patients with chronic atrophic gastritis and intestinal metaplasia express high levels of both CA19-9 and CEA.
为评估癌胚抗原（CEA）和糖类抗原19-9（CA19-9）的黏膜组织浓度在检测胃癌高危患者中的作用，对68例患者（45例男性，23例女性）进行了研究。对41例慢性浅表性胃炎、18例慢性萎缩性胃炎和9例胃癌患者的多次内镜活检获得的细胞溶胶进行CEA和CA19-9检测。从慢性浅表性胃炎到慢性萎缩性胃炎再到胃癌，CEA和CA19-9的黏膜组织浓度均升高（分别为p = 0.005和p = 0.002）。肠化生（IM）患者的黏膜CEA水平显著高于无化生的黏膜（p = 0.04）。与IM相比，上皮发育异常与CEA和CA19-9的组织浓度较高相关，尽管差异不显著。最后，仅观察到CA19-9的血清水平与组织浓度之间存在相关性（Pearson相关系数 = 0.7）。总之，这些数据表明，慢性萎缩性胃炎和肠化生患者的胃黏膜表达高水平的CA19-9和CEA。
