主要组织相容性复合体（MHC）多聚化、抗原表达与发育性免疫应答中抗原呈递细胞记忆缺失的诱导
MHC multimerization, antigen expression and the induction of APC amnesia in the developing immune response.
作者信息
Lake R A, Robinson B W, Hayball J D
机构信息
University Department of Medicine, Queen Elizabeth II Medical School, Nedlands, Perth, Australia.
出版信息
Immunol Cell Biol. 1999 Feb;77(1):99-104. doi: 10.1046/j.1440-1711.1999.00794.x.
Abstract
Class II multimer formation is an important event in immune recognition. Not only is multimerization a prerequisite for T cell activation, but it is a signal to APC. In the present article, we propose that multimerization can result in the specific removal of ligand complexes from the cell surface of the APC, an event which may influence the overall pattern of T cell reactivity.
摘要
II类多聚体形成是免疫识别中的一个重要事件。多聚化不仅是T细胞激活的前提条件，也是向抗原呈递细胞（APC）发出的信号。在本文中，我们提出多聚化可导致配体复合物从APC细胞表面特异性清除，这一事件可能会影响T细胞反应性的整体模式。
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