Gola E, Arosio G, Benedini G, Cicogna R, Petroboni V, Riva S, Rusconi C, Orlando G
G Ital Cardiol. 1976;6(2):279-89.
The onset of serious arrhythmias during potassium depletion occurs rather frequently in female subjects who have undergone hypotensive-diuretic treatment, independently from the duration and doses of drugs. These arrhythmias which produce a cardiac arrest, can also occur in subjects not affected with heart disease. They are not necessarily preceeded by clinical prodrumus or other types of minor arrhythmias not accompanied by other important electrocardiographic or serum-logical alterations of hypokaliemia. The most commonly observed type is the "torsades de pointe", though cases of ventricular tachycardia or ventricular fibrillation are also documented. The ethiopathogenesis is discussed with regard to the alterations of the basic electrocardiogram as well as to the kind of major arrhythmia. In most cases , lidocaine has given the most satisfactory thmias, results in the treatment of these arrhythmias, probably because of the modality of the action which is substantially different from the other antiarrhythmic drugs.
在接受降压利尿治疗的女性受试者中，低钾血症期间严重心律失常的发作相当频繁，与药物的使用时长和剂量无关。这些导致心脏骤停的心律失常，也可能发生在没有心脏病的受试者身上。它们不一定会先出现临床前驱症状或其他类型的轻微心律失常，且不会伴有低钾血症的其他重要心电图或血清学改变。最常见的类型是“尖端扭转型室速”，不过也有室性心动过速或心室颤动的病例记录。本文就基本心电图的改变以及主要心律失常的类型探讨了其病因发病机制。在大多数情况下，利多卡因在治疗这些心律失常方面取得了最令人满意的结果，这可能是因为其作用方式与其他抗心律失常药物有很大不同。
