Kieffer B L
CNRS UPR 9050, ESBS Parc d'innovation Bld S. Brandt, Illkirch, France.
Trends Pharmacol Sci. 1999 Jan;20(1):19-26. doi: 10.1016/s0165-6147(98)01279-6.
Opioid receptors of the mu-, delta- and kappa-subtypes mediate the potent analgesic and addictive actions of opioid drugs. They also regulate responses to pain, stress and emotions when activated by endogenous opioid peptides. Recently, mice lacking opioid receptors or opioid peptides have been produced by gene targeting, providing molecular tools to study opioid function in vivo. Observations on mutant mice have shed new light on the mode of action of opioids, opioid receptor heterogeneity and interactions, and the involvement of each component of the opioid system in mouse physiology. In this article, Brigitte L. Kieffer reviews the first reported studies and discusses their therapeutic implications.
μ、δ和κ亚型的阿片受体介导了阿片类药物强大的镇痛和成瘾作用。当被内源性阿片肽激活时，它们还调节对疼痛、压力和情绪的反应。最近，通过基因靶向技术培育出了缺乏阿片受体或阿片肽的小鼠，这为在体内研究阿片功能提供了分子工具。对突变小鼠的观察为阿片类药物的作用方式、阿片受体的异质性和相互作用，以及阿片系统的每个组分在小鼠生理学中的作用带来了新的认识。在本文中，布里吉特·L·基弗综述了首批报道的研究，并讨论了它们的治疗意义。
