Mattar F, Sibai B M
Department of Obstetrics and Gynecology, The University of Tennessee, Memphis 38103, USA.
Semin Perinatol. 1999 Feb;23(1):58-64. doi: 10.1016/s0146-0005(99)80060-3.
Preeclampsia is a multisystem disorder of unknown cause. Efforts to prevent the disease or reduce its incidence have utilized pharmacological intervention as well as dietary supplementation. Recent, large, randomized trials have not shown a benefit from the use of aspirin. Calcium supplementation has also been studied extensively and found to be similarly ineffective in reducing the incidence or severity of preeclampsia in healthy women. The studies regarding the use of magnesium, zinc, and fish oils for the prevention of preeclampsia are fewer in number, but have also found minimal to no benefit. In the same respect, numerous randomized trials have been performed using antihypertensive agents, diuretics, and low-salt diet. Results of these studies have not shown any beneficial effect. Prevention of preeclampsia is unlikely as long as the underlying origin remains unknown.
子痫前期是一种病因不明的多系统疾病。预防该疾病或降低其发病率的努力采用了药物干预以及膳食补充剂。近期的大型随机试验并未显示使用阿司匹林有任何益处。补钙也已得到广泛研究，结果发现其在降低健康女性子痫前期发病率或严重程度方面同样无效。关于使用镁、锌和鱼油预防子痫前期的研究数量较少，但也发现益处极小或没有益处。同样，已经进行了许多使用抗高血压药物、利尿剂和低盐饮食的随机试验。这些研究结果并未显示出任何有益效果。只要潜在病因不明，子痫前期就不太可能预防。
