Chaturvedi S, Lukovits T G, Chen W, Gorelick P B
Department of Neurology, Wayne State University/Detroit Medical Center, MI 48201, USA.
Neurology. 1999 Mar 23;52(5):980-3. doi: 10.1212/wnl.52.5.980.
Congenital variations in the configuration and size of the cerebral vessels may predispose to ischemic stroke.
OBJECTIVES/METHODS: To illustrate that a hypoplastic basilar artery may lead to posterior circulation ischemia in adults, eight cases are reported from two university medical centers.
Five men and three women with a mean age of 49.8 years are reported. Four of the patients had other conventional stroke risk factors. Two patients had brainstem strokes, and six had TIA. All patients had hypoplastic basilar arteries. Seven patients had at least one hypoplastic vertebral artery (bilateral in five cases), and six patients had both posterior cerebral arteries originating from the internal carotid arteries.
A hypoplastic basilar artery is frequently accompanied by vertebral artery hypoplasia, and this can predispose adults to posterior circulation ischemia. This entity can be suspected on the basis of MR angiogram, but conventional angiography will provide definitive diagnosis. Optimal medical and surgical treatment of this condition is unresolved.
脑血管的形态和大小的先天性变异可能易患缺血性中风。
目的/方法：为了说明发育不全的基底动脉可能导致成人后循环缺血，来自两个大学医学中心报告了8例病例。
报告了5名男性和3名女性，平均年龄49.8岁。4名患者有其他传统的中风危险因素。2名患者发生脑干中风，6名患者发生短暂性脑缺血发作（TIA）。所有患者均有发育不全的基底动脉。7名患者至少有1条椎动脉发育不全（5例为双侧），6名患者双侧大脑后动脉均起源于颈内动脉。
发育不全的基底动脉常伴有椎动脉发育不全，这可使成人易患后循环缺血。根据磁共振血管造影可怀疑有此情况，但传统血管造影可提供明确诊断。这种情况的最佳药物和手术治疗方法尚未解决。
