Hong Y, Pedersen N L, Egberg N, de Faire U
Division of Cardiovascular and Genetic Epidemiology, Institute of Environmental Medicine, the Karolinska Institute, Stockholm, Sweden.
Thromb Haemost. 1999 Mar;81(3):382-6.
Coagulation factor VII has been demonstrated as a potential risk factor for cardiovascular disease. Both genes and non-genetic factors are related to plasma levels of factor VII. However, the extent to which genetic effects influence variability in plasma factor VII levels is unknown. Further, increased levels of plasma factor VII are associated with serum triglycerides, yet the reason for this association is not fully understood.
Quantitative genetic analyses were applied to evaluate the relative importance of genetic and different environmental influences on plasma factor VII levels and to test the significance of genetic and environmental factors in common to factor VII and triglycerides in 215 pairs of middle-aged and elderly twins, of whom 104 were reared apart and 120 were women. Genetic influences were found to account for 57% of the individual differences in plasma factor VII levels, whereas shared-rearing and residual-familial environmental factors were not significant. Furthermore, a significant genetic correlation of 0.38 was found between factor VII and triglycerides, but the environmental correlation between these two measures was not significant. Genetic factors in common to factor VII and triglycerides explain about 7% of the total variance for factor VII.
The present study suggests that there are substantial genetic influences on plasma factor VII levels. Furthermore, genetic effects explain the phenotypic association between factor VII and triglycerides.
凝血因子VII已被证明是心血管疾病的一个潜在危险因素。基因和非基因因素均与血浆中因子VII的水平有关。然而，基因效应影响血浆因子VII水平变异性的程度尚不清楚。此外，血浆因子VII水平升高与血清甘油三酯有关，但其关联原因尚未完全明确。
应用定量遗传学分析来评估基因和不同环境因素对血浆因子VII水平的相对重要性，并检验215对中老年双胞胎中因子VII和甘油三酯共同的基因和环境因素的显著性，其中104对双胞胎是分开抚养的，120名是女性。研究发现基因影响占血浆因子VII水平个体差异的57%，而共同抚养和残余家庭环境因素并不显著。此外，因子VII与甘油三酯之间存在显著的遗传相关性，为0.38，但这两种指标之间的环境相关性并不显著。因子VII和甘油三酯共同的基因因素解释了因子VII总变异的约7%。
本研究表明，基因对血浆因子VII水平有显著影响。此外，基因效应解释了因子VII与甘油三酯之间的表型关联。
