Vara Prasad M V, Dhanasekaran N
Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA.
Oncogene. 1999 Feb 25;18(8):1639-42. doi: 10.1038/sj.onc.1202461.
The alpha-subunit of the heterotrimeric G protein G13 regulate cell growth, differentiation and apoptosis in different cell types. Expression of the constitutively activated mutant of G(alpha)13 (G(alpha13)QL) increases the expression of Egr-1, an immediate-early response gene that is identified to be involved in cell growth, differentiation, and apoptosis. Here we report that G(alpha13)QL activates the promoter of Egr-1 through specific sequence which includes the characteristic CArG boxes. We also demonstrate that the G(alpha13)QL activation of Egr-1 promoter is mediated by the Ras-like small GTPase Rho.
异源三聚体G蛋白G13的α亚基在不同细胞类型中调节细胞生长、分化和凋亡。组成型激活的G（α）13突变体（G（α13）QL）的表达增加了Egr-1的表达，Egr-1是一种即刻早期反应基因，已被确定参与细胞生长、分化和凋亡。在此我们报告，G（α13）QL通过包含特征性CArG框的特定序列激活Egr-1启动子。我们还证明，Egr-1启动子的G（α13）QL激活是由类Ras小GTP酶Rho介导的。
