Hoffmann W, Grospietsch G, Kuhn W
Geburtshilfe Frauenheilkd. 1976 Dec;36(12):1066-70.
Due to the close morphological relationships and the dependence of the genital system on inductive impulses from the uropoietic system, the possibility of an increased incidence of malformations in the area of the female genitals for thalidomide-damaged children is to be expected. This suspicion is supported by the accumulation of reports of genital malformations in deceased children from mothers who took thalidomide-containing medicaments during the early weeks of pregnancy. - A 14-year-old patient with malformations of both upper extremities whose mother had taken thalidomide during the 6th to the 9th week of pregnancy presented at our hospital with complaints of cyclic pain in the lower abdomen. Although the ovaries and fallopian tubes were normally developed, the uterus and the vagina were absent in this patient. After this manuscript had been completed, we heard of 3 additional cases of genital malformation with a known thalidomide anamnesis.
由于形态学关系密切以及生殖系统依赖来自泌尿生成系统的诱导冲动，对于沙利度胺致伤儿童，女性生殖器区域畸形发生率增加的可能性是可以预期的。孕期最初几周服用含沙利度胺药物的母亲所生已死亡儿童中生殖器畸形报告的积累支持了这一怀疑。——一名14岁双上肢畸形患者，其母亲在孕期第6至9周服用了沙利度胺，因下腹部周期性疼痛来我院就诊。尽管该患者卵巢和输卵管发育正常，但子宫和阴道缺如。在本稿件完成后，我们又听说了另外3例已知有沙利度胺病史的生殖器畸形病例。
