Faust J, Bewerunge A, Habedank M, Kopecky P
Geburtshilfe Frauenheilkd. 1976 Dec;36(12):1091-8.
The blood of 100 pregnant women was screened to detect Y-chromatin containing cells of the fetus for prenatal sex-determination. Obtaining 15% false predictions the previous rate of wrong diagnoses could not be reduced significantly. Studying the frequency of fetal leukocytes in the maternal circulation, a significant increase during the pregnancy could not be found. In early pregnancy lymphoid cells containing Y-chromatin can be found first in the 7th week and granulocytes in the 10th week. The prenatal fetal sex-determination from 13 pregnant women was done by chromosome studies, too. Their rate of false diagnoses was 0%. Screening the Y-chromatin containing cells of 13 women, who had given birth to a male child within the last 5 years, we were able to establish a survival of fetal lymphocytes in the maternal circulation within 25 months. An increase in fetal cells according to the length of time the cells were cultured, could not be detected.
对100名孕妇的血液进行筛查，以检测胎儿含Y染色质的细胞用于产前性别鉴定。由于存在15%的错误预测，之前的误诊率无法显著降低。研究母体循环中胎儿白细胞的频率，未发现孕期有显著增加。在妊娠早期，含Y染色质的淋巴细胞最早可在第7周发现，粒细胞在第10周发现。对13名孕妇进行了染色体研究以进行产前胎儿性别鉴定，其误诊率为0%。对13名在过去5年内生育了男婴的女性进行含Y染色质细胞筛查，我们得以确定胎儿淋巴细胞在母体循环中可存活25个月。未检测到胎儿细胞数量随培养时间的延长而增加。
