抗流感病毒药物金刚乙胺具有杀锥虫活性。
The anti-influenza virus drug rimantadine has trypanocidal activity.
作者信息
Kelly J M, Miles M A, Skinner A C
机构信息
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, United Kingdom.
出版信息
Antimicrob Agents Chemother. 1999 Apr;43(4):985-7. doi: 10.1128/AAC.43.4.985.
Abstract
We report here that bloodstream forms of the African trypanosome, Trypanosoma brucei, are sensitive to the anti-influenza virus drug rimantadine (50% inhibitory concentration of 1.26 micrograms ml-1 at pH 7.4). The activity is pH dependent and is consistent with a mechanism involving inhibition of the ability to regulate internal pH. Rimantadine is also toxic to the trypanosomatid parasites Trypanosoma cruzi and Leishmania major.
摘要
我们在此报告，非洲锥虫布氏锥虫的血流形式对抗流感病毒药物金刚烷胺敏感（在pH 7.4时50%抑制浓度为1.26微克/毫升）。其活性依赖于pH，并且与一种涉及抑制调节内部pH能力的机制一致。金刚烷胺对锥虫寄生虫克氏锥虫和硕大利什曼原虫也有毒性。
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