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Role of virion M2 protein in influenza virus uncoating: specific reduction in the rate of membrane fusion between virus and liposomes by amantadine.病毒粒子M2蛋白在流感病毒脱壳中的作用：金刚烷胺对病毒与脂质体之间膜融合速率的特异性降低。
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Understanding the mechanism of action of the anti-influenza virus drug amantadine.了解抗流感病毒药物金刚烷胺的作用机制。
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抗流感病毒药物金刚乙胺具有杀锥虫活性。

The anti-influenza virus drug rimantadine has trypanocidal activity.

作者信息

Kelly J M, Miles M A, Skinner A C

机构信息

Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, United Kingdom.

出版信息

Antimicrob Agents Chemother. 1999 Apr;43(4):985-7. doi: 10.1128/AAC.43.4.985.

DOI:10.1128/AAC.43.4.985
PMID:10103219
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC89245/
Abstract

We report here that bloodstream forms of the African trypanosome, Trypanosoma brucei, are sensitive to the anti-influenza virus drug rimantadine (50% inhibitory concentration of 1.26 micrograms ml-1 at pH 7.4). The activity is pH dependent and is consistent with a mechanism involving inhibition of the ability to regulate internal pH. Rimantadine is also toxic to the trypanosomatid parasites Trypanosoma cruzi and Leishmania major.

摘要

我们在此报告，非洲锥虫布氏锥虫的血流形式对抗流感病毒药物金刚烷胺敏感（在pH 7.4时50%抑制浓度为1.26微克/毫升）。其活性依赖于pH，并且与一种涉及抑制调节内部pH能力的机制一致。金刚烷胺对锥虫寄生虫克氏锥虫和硕大利什曼原虫也有毒性。