葡萄胎中的β-葡萄糖醛酸酶与雌激素

beta-Glucuronidase and oestrogens in hydatidiform mole.

作者信息

Leung K C, Lee Y T, Fung K P, Yu W N, Yu C C

出版信息

Clin Chim Acta. 1976 Nov 1;72(3):295-300. doi: 10.1016/0009-8981(76)90191-1.

Abstract

The activity of beta-glucuronidase (beta-D-glucuronide glycuronohydrolase, EC 3.2.1.31) in placental and hydatidiform mole tissue and in sera from non-pregnant, normal and molar pregnant women was determined. The oestrogen concentrations in the two solid tissues were also assayed. Significant differences were found in the activities of the enzyme between placental and molar tissues and among the various sera. The lower activity in molar serum corresponds to a lower concentration of oestrogens in molar tissues and may be regarded as a response to the alleviation of conjugation requirements.

摘要

测定了胎盘和葡萄胎组织以及非妊娠、正常妊娠和葡萄胎妊娠妇女血清中β-葡萄糖醛酸酶（β-D-葡萄糖醛酸葡萄糖醛酸水解酶，EC 3.2.1.31）的活性。还检测了这两种实体组织中的雌激素浓度。在胎盘组织和葡萄胎组织之间以及不同血清之间发现了该酶活性的显著差异。葡萄胎血清中较低的活性对应于葡萄胎组织中较低的雌激素浓度，这可能被视为对结合需求减轻的一种反应。