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A general method for optimal drug dose computation.

作者信息

Wheeler L A, Sheiner L B

出版信息

J Pharmacokinet Biopharm. 1976 Dec;4(6):487-97. doi: 10.1007/BF01064554.

DOI:10.1007/BF01064554
PMID:1011075
Abstract
摘要

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Continuous intravenous infusion and multicompartment accumulation.
Eur J Pharmacol. 1968 Oct;4(3):317-24. doi: 10.1016/0014-2999(68)90100-3.
2
General treatment of linear mammillary models with elimination from any compartment as used in pharmacokinetics.线性乳突模型的一般处理方法，即如药代动力学中所使用的那样，从任何隔室中消除。
J Pharm Sci. 1972 Apr;61(4):536-41. doi: 10.1002/jps.2600610408.
3
Pharmacokinetics of intravenous theophylline.静脉注射氨茶碱的药代动力学
Clin Pharmacol Ther. 1973 Jul-Aug;14(4):509-13. doi: 10.1002/cpt1973144part1509.
4
Reducation of digitalis toxicity by computer-assisted glycoside dosage regimens.通过计算机辅助糖苷给药方案降低洋地黄毒性
Ann Intern Med. 1972 Dec;77(6):891-906. doi: 10.7326/0003-4819-77-6-891.
5
Drug input optimization: bioavailability-effected time-optimal control of multiple, simultaneous, pharmacological effects and their interrelationships.
J Pharm Sci. 1972 Dec;61(12):1941-52. doi: 10.1002/jps.2600611212.
6
A safe method for rapidly achieving plasma concentration plateaus.一种快速达到血浆浓度平台期的安全方法。
Clin Pharmacol Ther. 1974 Oct;16(4):691-700. doi: 10.1002/cpt1974164691.
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Mathematical formulation for nonuniform multiple dosing.
J Pharm Sci. 1975 Mar;64(3):464-6. doi: 10.1002/jps.2600640328.
8
Improved computer-assisted digoxin therapy. A method using feedback of measured serum digoxin concentrations.
Ann Intern Med. 1975 May;82(5):619-27. doi: 10.7326/0003-4819-82-5-619.