Brancato D J, Picchioni A L, Chin L
J Toxicol Environ Health. 1976 Nov;2(2):351-9. doi: 10.1080/15287397609529438.
Rats that received cadmium 300 ppm in drinking water (average daily cadmium intake = 4.5 mg/rat) for 12 wk attained peak cadmium levels of 112, 34, and 19 mug/g in hair, liver, and kidney, respectively, at week 4. Rats that ingested cadmium 200 ppm (average daily cadmium intake = 3.6 mg/rat) for 13 wk attained peak cadmium levels of 29 mug/g in kidney at week 7, and 94 and 27 mug/g in hair and liver, respectively, at week 9. Despite continuous exposure to the heavy metal, tissue cadmium concentrations declined to steady-state levels of 24-33 mug/g in hair and 10-17 mug/g in liver and kidney. Histopathologic effects were not observed in liver or kidney. In contrast to cadmium in hair, blood cadmium levels, which remained consistently low (less than 0.04 mug/ml) throughout the study, did not correlate with changes in cadmium levels in liver and kidney.
饮用含300 ppm镉的水（平均每日镉摄入量 = 4.5毫克/只大鼠）达12周的大鼠，在第4周时毛发、肝脏和肾脏中的镉峰值水平分别达到112、34和19微克/克。摄入200 ppm镉（平均每日镉摄入量 = 3.6毫克/只大鼠）达13周的大鼠，在第7周时肾脏中的镉峰值水平达到29微克/克，在第9周时毛发和肝脏中的镉峰值水平分别达到94和27微克/克。尽管持续接触重金属，但组织中的镉浓度下降至毛发中24 - 33微克/克、肝脏和肾脏中10 - 17微克/克的稳态水平。在肝脏或肾脏中未观察到组织病理学效应。与毛发中的镉不同，在整个研究过程中血镉水平一直保持在较低水平（低于0.04微克/毫升），与肝脏和肾脏中镉水平的变化无关。
