Nakayama M, Machii K, Goto Y, Fujiwara K
Jpn J Exp Med. 1976 Oct;46(5):309-24.
Tyzzer's organisms from a hamster case were administered perorally to 6- to 8-week-old APG hamsters and the growth of organisms and lesions produced in the intestine and the liver were studied. When cortisone was given after oral infection with 2 X 10(5) or more organisms, most animals died in 4 to 7 days showing severe necrotic lesions in the liver but no diarrhea was observed. Without cortisone, watery diarrhea was seen between 2 and 7 days after infection and some animals died in 7 to 13 days. Dead and surviving animals showed liver lesions to a lesser degree as compared to those with cortisone treatment. Two days after inoculation either with or without cortisone, a number of organisms were found within mucosal epithelial cells of the cecum and colon, and 1 or 2 days later when focal necrosis occurred in the liver, they were also found in the duodenum, jejunum and ileum. Inoculated into a ligated cecal sac, organisms were shown to multiply in epithelial cells and the lamina propria of the ligated sac, then producing hepatic lesions in 3 to 4 days when bacterial growth was not detected at any other parts of intestines, suggesting that organisms might gain access to the liver from the cecum via the portal circulation or lacteals.
将一只仓鼠病例中的泰泽氏菌经口接种到6至8周龄的APG仓鼠体内，研究该菌的生长情况以及在肠道和肝脏中产生的病变。当口服感染2×10⁵或更多菌后给予可的松时，大多数动物在4至7天内死亡，肝脏出现严重坏死性病变，但未观察到腹泻。未给予可的松时，感染后2至7天出现水样腹泻，一些动物在7至13天内死亡。与接受可的松治疗的动物相比，死亡和存活动物的肝脏病变程度较轻。接种可的松与否，接种后两天，在盲肠和结肠的黏膜上皮细胞内发现大量细菌，1或2天后肝脏出现局灶性坏死时，在十二指肠、空肠和回肠中也发现了细菌。将细菌接种到结扎的盲肠囊中，结果显示细菌在结扎囊的上皮细胞和固有层中繁殖，然后在3至4天内产生肝脏病变，此时在肠道的任何其他部位均未检测到细菌生长，这表明细菌可能通过门静脉循环或乳糜管从盲肠进入肝脏。
