Itoh T, Kagiyama N, Fujiwara K
Central Institute for Experimental Animals, Kawasaki, Japan.
Jpn J Exp Med. 1989 Feb;59(1):9-15.
Tyzzer's disease was produced in rats by peroral inoculation with spores of Bacillus piliformis (Tyzzer's organism) of rat origin. After ingestion of 10(6) spores necrotized lesions with intracellular bacterial propagation were seen in the intestines, liver and heart on days 2 to 14 postinoculation (p.i.). A number of B. piliformis were present within enterocytes of the cecum and colon. Infected cells were also seen in the liver, myocardium and intestinal muscle layers on days 3 to 7 p.i. Infective spores were found to be shed in feces during 3 to 10 days p.i.
通过经口接种源自大鼠的梨形芽孢杆菌（泰泽氏菌）的孢子，在大鼠中引发了泰泽氏病。摄入10⁶个孢子后，在接种后第2至14天，在肠道、肝脏和心脏中可见伴有细胞内细菌繁殖的坏死性病变。盲肠和结肠的肠上皮细胞内存在大量梨形芽孢杆菌。在接种后第3至7天，在肝脏、心肌和肠肌层中也可见到受感染的细胞。在接种后3至10天内，发现粪便中排出感染性孢子。
