Saks V A, Gukovskiĭ D E, Lipina N V, Smirnov V N, Chazov E I
Kardiologiia. 1976 Sep;16(9):72-9.
The method of mathematical modelling and kynetic analysis was used to study the mechanism of the regulatory effect of magnesium ions on the creatinephosphokinase reaction in cardiac mitochondria. The regulatory effect of magnesium was shown to originate from the competition between ATP and ADP and the magnesium-complex-formation reaction, and the actual regulator proves to be MgADP. On the basis of the data obtained it is postulated that creatinephosphokinase in cardiac mitochondria is functionally connected with ATP-ADP-translocase. The obtained data permit to believe that the mitochondrial cratinephosphokinase is one of the key links in the process of energy transport in the cardiac cells.
采用数学建模和动力学分析方法研究镁离子对心肌线粒体中肌酸磷酸激酶反应的调节作用机制。结果表明，镁的调节作用源于ATP与ADP之间的竞争以及镁络合物形成反应，实际调节因子为MgADP。根据所得数据推测，心肌线粒体中的肌酸磷酸激酶在功能上与ATP-ADP转位酶相关。所得数据使人相信，线粒体肌酸磷酸激酶是心肌细胞能量转运过程中的关键环节之一。
