Counahan R, El-Bishti M, Cox B D, Ogg C S
Kidney Int. 1976 Dec;10(6):471-7. doi: 10.1038/ki.1976.134.
Fasting plasma amino acid concentrations were measured in 16 children on regular hemodialysis for renal failure. Reductions compared to normal were found in valine, leucine, isoleucine, lysine, histidine, tyrosine, and serine; and increases were found in glycine, citruline, proline, and 1- and 3-methylhistidine. Acute reductions in amino acid concentrations occurred in response to i.v. glucose, similar to those reported in normal adults, but plasma alanine, which was raised only in those with poor glucose tolerance, fell to normal and did not vary in those with normal glucose tolerance. No correlations were found with growth, but the plasma glycine concentration was highest in those patients with poorest energy intakes. Plasma alanine concentrations correlated with raised triglyceride concentrations. It is suggested that many of the abnormalities are due to the excessive utilization of protein for energy because of impaired availability of conventional energy sources in uremia.
对16名因肾衰竭接受定期血液透析的儿童测定了空腹血浆氨基酸浓度。与正常水平相比，缬氨酸、亮氨酸、异亮氨酸、赖氨酸、组氨酸、酪氨酸和丝氨酸浓度降低；甘氨酸、瓜氨酸、脯氨酸以及1-甲基组氨酸和3-甲基组氨酸浓度升高。静脉注射葡萄糖后，氨基酸浓度急性降低，这与正常成年人的情况相似，但只有糖耐量差的患者血浆丙氨酸升高，其降至正常水平，而糖耐量正常的患者血浆丙氨酸无变化。未发现与生长相关，但能量摄入最差的患者血浆甘氨酸浓度最高。血浆丙氨酸浓度与甘油三酯浓度升高相关。提示许多异常情况是由于尿毒症中传统能量来源可用性受损，导致蛋白质过度用于供能所致。
