甲苯磺丁脲、格列本脲、HB 699及葡萄糖对胃肠切除犬血清胰岛素和血糖影响的研究。
Studies on the effect of tolbutamide, glibenclamide, HB 699, and glucose on serum insulin and blood glucose in gastro-enterectomized dogs.
作者信息
Bickel M, Geisen K, Schleyerbach R
出版信息
Arch Int Pharmacodyn Ther. 1978 Jul;234(1):118-38.
The influence of intravenously administered tolbutamide, glibenclamide, HB 699, and glucose on serum insulin and blood glucose kinetics was examined in 36 enterectomized dogs. The substances induced an immediate and long-lasting insulin release even in the absence of all insulinotropic intestinal mediators. Maximum and mean insulin concentrations after treatment, measured for 180 minutes, were markedly higher in resected dogs than in sham operated or non-operated animals. The data suggest that intestinal mediators might be of no importance in vivo for the insulin-releasing activity of the compounds examined, at least in dogs.
在36只肠切除犬中研究了静脉注射甲苯磺丁脲、格列本脲、HB 699和葡萄糖对血清胰岛素和血糖动力学的影响。即使在没有所有促胰岛素分泌的肠道介质的情况下，这些物质也能引起即时且持久的胰岛素释放。在180分钟内测量的治疗后最大和平均胰岛素浓度，在切除犬中明显高于假手术或未手术的动物。数据表明，至少在犬中，肠道介质在体内对于所研究化合物的胰岛素释放活性可能并不重要。
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