Mérillon J P, Zygelman M, Baudouy Y, Masquet C, Aubier M, Gourgon R
Arch Mal Coeur Vaiss. 1978 Aug;71(8):887-95.
Thirty-two patients (group I: 7 normal subjects; group II: 25 coronary subjects) underwent coronary arteriography, and measurements were made both in normal rhythm and under atrial stimulation of the pulmonary capillary pressure and the pressure in the femoral artery, of cardiac output, of coronary sinus flow (by continuous thermodilution), of the coronary arterio-venous oxygen difference, of oxygen consumption, and in 28 of the patients of the coefficient of extraction of K lactates. During stimulation, the only differences to appear between the subjects of group I and group II were an increase in capillary pressure (p less than 0.01) and a decrease in the coefficient of extraction of lactates (p less than 0.001) in the coronary patients. Similar differences were found between coronary patients with a stenosis greater than 70% in the anterior descending or circumflex artery (group IIa) and those without it (group 11b), and between the patients with pain during atrial stimulation (n = 9) and those without it. There was a good correlation between a double score (IVA + circumflex artery, Rowe's method) and the coefficient of extraction of lactates during atrial stimulation (n = 28, p less than 0.01).
32例患者（I组：7名正常受试者；II组：25名冠心病患者）接受了冠状动脉造影，并在正常心律及心房刺激下测量了肺毛细血管压、股动脉压、心输出量、冠状窦血流量（通过连续热稀释法）、冠状动脉动静脉氧差、氧耗量，且在28例患者中测量了乳酸提取系数。在刺激过程中，I组和II组受试者之间仅出现的差异是冠心病患者的毛细血管压升高（p<0.01）以及乳酸提取系数降低（p<0.001）。在前降支或回旋支动脉狭窄大于70%的冠心病患者（IIa组）与无此情况的患者（IIb组）之间，以及在心房刺激时有疼痛的患者（n=9）与无疼痛的患者之间，也发现了类似差异。双计分（IVA+回旋支动脉，罗方法）与心房刺激时的乳酸提取系数之间存在良好相关性（n=28，p<0.01）。
