Suc J M, Gassia J P, Orfila C, Durand D
Arch Mal Coeur Vaiss. 1978 Jul;71 Spec No:30-8.
Although the term hypertension in pregnancy is a simple and uncontroversial one, it unfortunately encompasses some ill defined clinical conditions as well as pre-eclampsia. The prime cause of pre-eclampsia is utero-placental ischaemia. Such utero-placental ischaemia is responsible for the hypothetical secretion of a vasopressor agent and for intravascular coagulation. An immunological cause should also be suspected: a study of the immune profile of the kidney has shown that the glomerular capillaries contain immunoglobulins G and M as well as the C3 fraction of complement. Renal biopsies carried out three months after delivery have shown deposits of C3 in the arteriolar walls. During normal pregnancy, there exists a state of stable equilibrium of hormonal, haemodynamic, haematological and immunological factors. It seems that all components of this equilibrium are disturbed in cases of hypertension in pregnancy.
尽管妊娠期高血压这一术语简单且无争议，但遗憾的是，它涵盖了一些定义不明确的临床病症以及先兆子痫。先兆子痫的主要病因是子宫胎盘缺血。这种子宫胎盘缺血会导致一种血管加压物质的假设性分泌以及血管内凝血。还应怀疑存在免疫方面的病因：对肾脏免疫特征的一项研究表明，肾小球毛细血管含有免疫球蛋白G和M以及补体的C3成分。产后三个月进行的肾活检显示小动脉壁有C3沉积。在正常妊娠期间，激素、血流动力学、血液学和免疫学因素处于稳定的平衡状态。在妊娠期高血压的情况下，这种平衡的所有组成部分似乎都受到了干扰。
