Schalk D C, Wilson W H
Dammasch State Hospital, Wilsonville, OR 97070.
Hosp Pharm. 1993 Jul;28(7):647-53.
Medical records of 90 consecutive patients who started clozapine were reviewed to see how this drug is being used with other psychotropic medications and to evaluate what impact it has had on the drug regimens of these patients. Data from up to 6 months before to 12 months after clozapine's initiation was included. The percent of patients receiving medications for antipsychotic side effects decreased from 86% 6 months prior to clozapine to 13% 12 months after. The use of benzodiazepines decreased from 43% to 23% during this time period as did lithium use from 57% to 17%. While 28% of the patients were receiving carbamazepine prior to starting clozapine, no patients remained on this drug concurrently with clozapine. The average number of psychiatric medications per patient decreased from 3.39 +/- 1.37 6 months prior to clozapine to 1.61 +/- .83 at month 12. Concern for drug interactions along with clozapine's reduced incidence of extrapyramidal side effects and increased efficacy contributed to the reduction in medication use observed.
回顾了90例开始使用氯氮平的连续患者的病历，以了解该药物与其他精神药物联合使用的情况，并评估其对这些患者药物治疗方案的影响。纳入了氯氮平开始使用前6个月至使用后12个月的数据。接受抗精神病药物副作用治疗的患者比例从氯氮平使用前6个月的86%降至使用后12个月的13%。在此期间，苯二氮䓬类药物的使用从43%降至23%，锂盐的使用从57%降至17%。虽然28%的患者在开始使用氯氮平之前正在服用卡马西平，但没有患者在使用氯氮平的同时继续服用该药物。每位患者使用的精神科药物平均数量从氯氮平使用前6个月的3.39±1.37降至第12个月的1.61±0.83。对药物相互作用的关注以及氯氮平锥体外系副作用发生率的降低和疗效的提高，促成了所观察到的药物使用减少。
