Vanhoof R, Vanderlinden M P, Hubrechts J M, Butzler J P, Yourassowsky E
Br J Vener Dis. 1978 Oct;54(5):309-15. doi: 10.1136/sti.54.5.309.
The minimum inhibitory concentrations (MICs) of 18 antimicrobial agents against 104 strains of Neisseria gonorrhoeae isolated in the Brussels area between January and October 1976 have been measured. The MICs for penicillin G, ampicillin, amoxycillin, carbenicillin, and cephalexin showed a bimodal distribution. The second modus strains of cephalexin (MIC = 6.25 microgram/ml) were relatively resistant to penicillin G (MIC greater than or equal to 0.08 microgram/ml). About 51% of all strains were relatively resistant to penicillin G, 40.5% to ampicillin (MIC greater than or equal to 0.16 microgram/ml), 46% to amoxycillin, and 47.5% to carbenicillin. For cephalexin and cephaloridine, 25% and 8.5% respectively of all strains were relatively resistant (MIC greater than 3.12 microgram/ml). For cefazolin all MICs fell into a range of 0.097--3.12 microgram/ml. Resistance to tetracycline, doxycycline, minocycline, erythromycin, and spiramycin (MIC greater than or equal to 1 microgram/ml) was found in 9.5%, 7%, 6%, 36.5%, and 71% respectively of all isolates. No strains were resistant to rifampicin. For chloramphenicol and thiamphenicol the MICs ranged from 0.39 to 12.5 microgram/ml and from 0.195 to 3.12 microgram/ml respectively. The results for sulphamethoxazole, trimethoprim, and the combination of sulphamethoxazole and trimethoprim in a 20:1 ratio are given and discussed. The fractional inhibitory concentration (FIC) indices have also been calculated. No beta-lactamase-producing strains were found, and a contingency coefficient C has been determined for all the pairs of antibiotics investigated.
测定了18种抗菌剂对1976年1月至10月间在布鲁塞尔地区分离出的104株淋病奈瑟菌的最低抑菌浓度（MIC）。青霉素G、氨苄西林、阿莫西林、羧苄西林和头孢氨苄的MIC呈双峰分布。头孢氨苄的第二个众数菌株（MIC = 6.25微克/毫升）对青霉素G相对耐药（MIC大于或等于0.08微克/毫升）。所有菌株中约51%对青霉素G相对耐药，40.5%对氨苄西林（MIC大于或等于0.16微克/毫升）相对耐药，46%对阿莫西林相对耐药，47.5%对羧苄西林相对耐药。对于头孢氨苄和头孢噻啶，所有菌株中分别有25%和8.5%相对耐药（MIC大于3.12微克/毫升）。对于头孢唑林，所有MIC都在0.097 - 3.12微克/毫升范围内。在所有分离株中，对四环素、多西环素、米诺环素、红霉素和螺旋霉素（MIC大于或等于1微克/毫升）的耐药率分别为9.5%、7%、6%、36.5%和71%。没有菌株对利福平耐药。氯霉素和甲砜霉素的MIC分别为0.39至12.5微克/毫升和0.195至3.12微克/毫升。给出并讨论了磺胺甲恶唑、甲氧苄啶以及20:1比例的磺胺甲恶唑与甲氧苄啶组合的结果。还计算了部分抑菌浓度（FIC）指数。未发现产β-内酰胺酶的菌株，并确定了所研究的所有抗生素对的列联系数C。
