前列腺素F2α和E1的中枢效应。
Central effects of prostaglandins F2alpha and E1.
作者信息
Herman Z S, Kmieciak-Kolada K, Wolny H L, Slomińska-Zurek J, Bonczek A
出版信息
Pol J Pharmacol Pharm. 1976;28(5):411-21.
In male Wistar rats PGF2alpha or PGE1 were injected intracerebroventricularly (icv) in a dose of 1 or 10 mug. Immediately or 1 hr after injection the locomotor and exploratory activity were measured. The levels of noradrenaline (NA), dopamine (DA) 5-hydroxytryptamine (5-HT), 5-hydroxyindoleacetic acid (5-HIAA) and acetylcholine (Ach) were measured in discrete brain areas. Both PGs applied ivc caused the depression of locomotor and exploratory activity in rats. PGE1 acted longer. Both substances but PGE1 more intensively affected the level of estimated biogenic amines in different brain structures. It is concluded that PGF2alpha and E1 are central nervous depressants. Both PGs affect neurons producing NA or 5-HT or Ach in discrete areas of brain in different manner. There is different susceptibility of brain structures on PGs action.
在雄性Wistar大鼠中，以1或10微克的剂量脑室内注射前列腺素F2α（PGF2α）或前列腺素E1（PGE1）。注射后立即或1小时后测量其运动和探索活动。在离散的脑区测量去甲肾上腺素（NA）、多巴胺（DA）、5-羟色胺（5-HT）、5-羟吲哚乙酸（5-HIAA）和乙酰胆碱（Ach）的水平。静脉注射脑室内两种前列腺素均导致大鼠运动和探索活动受到抑制。PGE1的作用持续时间更长。两种物质，但PGE1更强烈地影响不同脑结构中估计的生物胺水平。得出结论，PGF2α和E1是中枢神经抑制剂。两种前列腺素以不同方式影响脑离散区域中产生NA、5-HT或Ach的神经元。脑结构对前列腺素作用的敏感性不同。
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