前列腺素A1、E1、E2、F1α和F2α在大鼠体内的中枢作用比较。II. 脑室内前列腺素对大鼠体内某些药物作用以及生物胺水平和周转的影响。
A comparison of the central actions of prostaglandins A1, E1, E2, F1alpha, and F2alpha in the rat. II. The effect of intraventricular prostaglandins on the action of some drugs and on the level and turnover of biogenic amines in the rat brain.
作者信息
Poddubiuk Z M, Kleinrok Z
出版信息
Psychopharmacology (Berl). 1976 Oct 20;50(1):95-102. doi: 10.1007/BF00634162.
Prostaglandins (PGs) injected into the right lateral brain ventricle (i.v.c.) of the rat increased the sleeping time induced by hexobarbital, chloral hydrate, and ethanol. PGE1 and PGE2 intensified chlorpromazine-induced catalepsy, inhibited amphetamine hyperactivity, and significantly depressed the amphetamine-induced stereotypy. NA concentrations were decreased by PGE1 and PGE2 and were increased by PGF2alpha. PGF2alpha increased both 5-HT and 5-HIAA levels in rat brain. "Total" ACh concentrations were increased by PGF1alpha and PGF2alpha. PGE1, PGE2, and PGF2alpha enhanced the turnover of NA, DA, and 5-HT. PGE2 counteracted the decreased activity induced by alpha-MT and abolished the hypothermic action of alpha-MT. PGF2alpha had little effect on the activity of PCPA pretreated rats, whereas the higher doses of PGF2alpha increased body temperature in these animals.
将前列腺素（PGs）注入大鼠右侧脑室（i.v.c.）会增加由己巴比妥、水合氯醛和乙醇诱导的睡眠时间。前列腺素E1（PGE1）和前列腺素E2（PGE2）会加剧氯丙嗪诱导的僵住症，抑制苯丙胺引起的多动，并显著抑制苯丙胺诱导的刻板行为。去甲肾上腺素（NA）浓度会因PGE1和PGE2而降低，因前列腺素F2α（PGF2α）而升高。PGF2α会提高大鼠脑中5-羟色胺（5-HT）和5-羟吲哚乙酸（5-HIAA）的水平。“总”乙酰胆碱（ACh）浓度会因前列腺素F1α（PGF1α）和PGF2α而升高。PGE1、PGE2和PGF2α会增强NA、多巴胺（DA）和5-HT的周转。PGE2可抵消α-甲基酪氨酸（α-MT）诱导的活性降低，并消除α-MT的降温作用。PGF2α对经对氯苯丙氨酸（PCPA）预处理的大鼠的活性影响不大，而较高剂量的PGF2α会使这些动物的体温升高。
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