Grabowska I, Kaliszan R
Pol J Pharmacol Pharm. 1976;28(5):529-36.
Crystalline samples of barbital obtained by isothermal crystallization from various solvents or by sublimation were analysed. Morphological, thermomicroscopical, thermal, IR, density and initial dissolution rate studies were carried out. X-ray analysis according to Debye-Scherrer was realised after 9-month storage of samples at room conditions. The ability of barbital to form polymorphic modifications was confirmed but the conclusions of previous works were discussed. It was found that the stability of metastable crystal structures II, III and IV was high enough to make them commercially feasible.
对通过从各种溶剂中进行等温结晶或升华获得的巴比妥晶体样品进行了分析。开展了形态学、热显微镜、热学、红外光谱、密度及初始溶解速率研究。在室温条件下将样品储存9个月后，根据德拜-谢乐法进行了X射线分析。证实了巴比妥具有形成多晶型变体的能力，但对先前研究的结论进行了讨论。发现亚稳晶体结构II、III和IV的稳定性足够高，使其具有商业可行性。
